Localized Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis

    August 2015 in “ Sultan Qaboos University medical journal ”
    Kawther El-Shafie, Nafisa Samir, Ritu Lakhtakia, Robin Davidson, Ahmed Al-Waili, Muna Al-Mamary, Mohammed Al-Shafee
    TLDR Vitamin B12 deficiency can cause skin darkening and other symptoms, which improve with B12 supplements.
    A 28-year-old man exhibited localized hyperpigmentation, numbness, anorexia, and weight loss, which were attributed to vitamin B12 deficiency due to chronic atrophic gastritis. His symptoms improved significantly with B12 supplementation. This case underscored the need to consider B12 deficiency in patients with unexplained hyperpigmentation and atypical symptoms for early detection and treatment to prevent complications.
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