TLDR Vitamin B12 deficiency can cause skin darkening and other symptoms, which improve with B12 supplements.
A 28-year-old man exhibited localized hyperpigmentation, numbness, anorexia, and weight loss, which were attributed to vitamin B12 deficiency due to chronic atrophic gastritis. His symptoms improved significantly with B12 supplementation. This case underscored the need to consider B12 deficiency in patients with unexplained hyperpigmentation and atypical symptoms for early detection and treatment to prevent complications.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
98 citations
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October 2012 in “Dermatologic Clinics” Eating the right nutrients can improve hair health, but taking extra supplements usually doesn't help unless you have a deficiency.
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May 2021 in “Journal of endocrinological investigation” APS-1 in Italy shows diverse AIRE mutations and various autoimmune issues.
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November 2010 in “Otolaryngologic Clinics of North America” Recognizing oral symptoms can help diagnose and treat blood and nutritional diseases early.
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June 2010 in “Clinics in Dermatology” Certain groups may need vitamin supplements to improve hair health and prevent other health problems.
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January 2004 in “Dermatologic Clinics” Skin problems in older people can indicate hormonal diseases, nutritional deficiencies, or conditions like diabetes, menopause, and HIV.