Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency

    October 2016 in “ Nutrition in clinical practice
    Leeda Tayem, Noureddine Litaiem, M. Jones, Faten Zéglaoui
    TLDR Vitamin B12 deficiency can cause facial dark spots that go away with treatment.
    The document reported a rare case of reversible melasma-like cutaneous hyperpigmentation associated with vitamin B12 deficiency, specifically pernicious anemia. The patient exhibited localized hyperpigmentation on the face, which is less commonly described compared to generalized hyperpigmentation. The study highlighted the importance of recognizing vitamin B12 deficiency as a potential cause of hyperpigmentation and discussed possible mechanisms behind this association. The condition was reversible upon treatment of the vitamin B12 deficiency.
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