July 2024 in “Journal of Pediatric Endocrinology and Metabolism” This study presents two adolescent cases of ovarian hyperthecosis, a rare cause of severe hyperandrogenism, highlighting management strategies involving gonadotropin suppression and hormone replacement after excluding androgen-producing adrenal and ovarian tumors.
April 2019 in “Journal of the Endocrine Society” This case report described a 62-year-old postmenopausal woman with hirsutism whose symptoms improved after a hysterectomy and bilateral oophorectomy, revealing bilateral ovarian hyperthecosis.
1 citations
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June 2024 in “Revista Colombiana de Endocrinología Diabetes & Metabolismo” This review concluded that for women, the benefits of testosterone implants are outweighed by risks, with possible higher rates of irreversible adverse effects than previously reported.
12 citations
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August 2011 in “European Journal of Endocrinology” This study found that anti-Müllerian hormone (AMH) is a valuable primary variable for classifying functional androgenization, especially in distinguishing ovarian-related groups, and supports the novel stratification system.
January 2017 in “University journal of surgery and surgical specialities” This case study describes a rare steroid cell tumor of the ovary in a 42-year-old woman, highlighting its virilizing effects and the importance of thorough follow-up due to its potential for malignancy.
November 2018 in “Endocrine Abstracts” A woman's high testosterone levels were caused by a rare ovarian tumor, not the initially diagnosed condition.
June 2020 in “AACE clinical case reports” This case report illustrates that Leydig cell tumors, despite causing significantly elevated androgen levels, can be difficult to localize due to their small size, as demonstrated in a 42-year-old woman whose tumor was only identified after oophorectomy.
September 2021 in “Conference Proceedings” This study observed that hyperandrogenism in men manifests with varying symptoms, where older men may have high total testosterone due to increased SHBG without elevated free testosterone, while younger men often show signs like acne and alopecia with elevated DHT or testosterone.
Hirsutism is relatively common among young Greek women.
This thesis examines the medicalization of the male and female body from the 19th century to the present, highlighting how biomedicine has shaped norms around health and illness.
6 citations
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April 2022 in “Biomedicines” This study found that SARS-CoV-2 infection was associated with significant upregulation of miR-371a-3p in testicular tissues and serum, leading to androgen receptor downregulation and decreased spermatogenesis in patients.
54 citations
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November 1995 in “The Journal of Clinical Endocrinology & Metabolism” In this study, females with 5 alpha-reductase-2 deficiency exhibited decreased body hair, normal sebum production, and delayed menarche, suggesting a role for DHT in hair growth and menstrual function.
1 citations
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January 2021 in “Prague medical report” This article reviews the potential male equivalent of polycystic ovarian syndrome, focusing on hormonal alterations and premature androgenic alopecia, but reports no new clinical findings; the authors highlight the need for further studies on adrenal steroids and other factors.
July 2025 in “Clinical Endocrinology” This study of Indian women aged 18-40 observed that oligo-anovulation and clinical hyperandrogenism were prevalent, found in 21.5% and 21% of participants respectively, with biochemical hyperandrogenism and subclinical hypothyroidism also noted as common endocrine dysfunctions.
September 2006 in “Pediatrics in Review” This case report highlights a 16-year-old girl with primary amenorrhea diagnosed with complete androgen insensitivity syndrome after chromosomal analysis revealed a 46,XY karyotype.
4 citations
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January 1991 in “Journal of obstetrics and gynaecology” This study found that both spironolactone with Ovysmen and cyproterone acetate with ethinyloestradiol significantly reduced hair growth in hirsute women, with no difference in effect between treatments.
October 2023 in “Journal of the Endocrine Society” In this case report, a post-menopausal woman with symptoms such as hirsutism and elevated testosterone underwent surgery, which revealed hormonally active ovarian cellular fibromas, leading to symptom resolution and normalized hormone levels; the authors suggest further exploration of these tumors' hormonal effects.
January 2025 in “Haematology International Journal” This study describes a functional disorder in the ovary, known as stromal hyperplasia, characterized by the proliferation of ovarian stroma and luteinization of stromal cells, which is linked to excessive androgen production and elevated testosterone levels.
October 1995 in “Pediatric Research”
September 2021 in “Physiology News” This abstract provides template specifications for design materials but reports no new research findings.
8 citations
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March 2008 in “Deutsche medizinische Wochenschrift/Deutsche Medizinische Wochenschrift” This case study found that in a male-to-female transgender individual, long-term cyproterone use led to decreased bone mass, which improved with additional oestradiol treatment, highlighting the anabolic role of oestrogens on bone health.
24 citations
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December 1988 in “British Journal of Dermatology” This study found no correlation between acne severity and clinical signs of androgenicity in women, suggesting factors other than hyperandrogenaemia may contribute to acne development.
May 2021 in “Journal of the Endocrine Society” This case report describes the rare association of an ovarian Leydig cell tumor and primary hyperparathyroidism in a postmenopausal woman, highlighting the importance of considering rare causes in patients with virilizing symptoms.
7 citations
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December 1987 in “Fertility and sterility” The vellus index is a simple, quick, and reliable method to assess and monitor hair growth, especially in hirsutism.
This study found that testosterone and finasteride were significantly associated with reports of male-factor infertility based on FDA pharmacovigilance data from 2010 to 2020.
December 2022 in “Cureus” This study found that clinical and biochemical markers of hyperandrogenism were more common in post-adolescent and early adult-onset acne among women than in adolescent acne.
7 citations
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April 2000 in “Archives of Pathology & Laboratory Medicine” This case report describes the first observed cytologic changes in gynecomastia associated with finasteride therapy, emphasizing that cytoplasmic vacuolization should not be mistaken for malignancy.
October 2024 in “Journal of the Endocrine Society” This report describes varied causes of hirsutism in young females and highlights the need to revise diagnoses if initial treatments for common etiologies like PCOS do not yield results.
32 citations
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September 2018 in “Clinical Obstetrics and Gynecology” This article states that hormone therapy with estrogens and antiandrogens for transgender females is within an obstetrician-gynecologist's practice scope and involves careful dosing and monitoring to manage short-term thrombotic risks.
April 2015 in “The FASEB Journal” In this study, perinatal androgen deprivation in male rats led to elevated estrogen levels and a lack of sexual motivation towards gonadally-intact female rats.