Case Report: Exceptional Association of Leydig Cell Ovarian Tumor and Primary Hyperparathyroidism in a Postmenopausal Patient

The document is a case report of a 55-year-old postmenopausal woman who presented with symptoms of hyperandrogenism, including hirsutism and male pattern hair loss. She was found to have significantly elevated testosterone levels and mild hypercalcemia, consistent with primary hyperparathyroidism (PHPT). A hypoechoic lesion in the left ovary, identified on a pelvic ultrasound, was consistent with an ovarian Leydig cell tumor, a rare type of tumor that accounts for less than 0.1% of all ovarian tumors. After undergoing bilateral Hysterosalpingo-oophorectomy, the patient reported improvement of hyperandrogenism symptoms. This case is notable due to the rare association of ovarian Leydig cell tumor and PHPT, making it the second such case reported in literature. The authors conclude that careful identification and reporting of cases with unusual clinical presentations is essential to better understand the pathophysiology of uncommon diseases and guide their management.