March 2024 in “Healthcare” Stem cell treatment improved life quality and sexual function in women with hair loss.
35 citations,
May 2012 in “Expert Opinion on Pharmacotherapy” The document concludes that there are various treatments for different types of alopecia, but more research is needed for evidence-based treatments.
October 2015 in “Elsevier eBooks” Aldesleukin can treat certain cancers and increase HIV patient CD4+ counts but often causes severe side effects.
51 citations,
October 2019 in “Cells” Baricitinib reduces inflammation and improves cell health in premature aging cells.
55 citations,
October 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” The review suggests that other immune cells besides CD8+ T cells may contribute to alopecia areata and that targeting regulatory cell defects could improve treatment.
11 citations,
January 2000 in “Journal of Cutaneous Pathology” Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.
59 citations,
November 2010 in “Circulation Research” Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.
24 citations,
August 2017 in “Prostaglandins & Other Lipid Mediators” CRTH2 antagonists might be useful for treating many conditions because they play a role in immune and inflammation responses.
9 citations,
October 2017 in “Translational pediatrics” Pediatric endocrinologists should provide early fertility counseling and preservation options to young patients at risk of infertility.
119 citations,
November 2016 in “American journal of human genetics” Mutations in three genes cause Uncombable Hair Syndrome, leading to frizzy hair that can't be combed flat.
2 citations,
November 2022 in “Journal of Biochemistry and Molecular Biology” Aging changes hair stem cells and their environment, leading to gray hair and hair thinning, but understanding these changes could help develop treatments for hair regeneration.
1 citations,
March 2024 in “International journal of molecular sciences” Radiation therapy damages skin structure and immune function, causing inflammation and potential hair loss.
131 citations,
September 2017 in “Molecular and Cellular Endocrinology” The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
February 2008 in “Experimental dermatology” Oxidative stress plays a significant role in vitiligo, and both skin and non-skin cells may be involved.
1 citations,
August 2000 in “Expert Opinion on Therapeutic Patents” Boosting mitochondrial energy production with supplements like acetyl-L-carnitine may improve aging-related cellular function and health conditions.
6 citations,
January 2018 in “Advances in experimental medicine and biology” Researchers created artificial human skin using special cells, which could help treat skin conditions like albinism and vitiligo.
25 citations,
November 2018 in “Cell reports” The study concluded that specific proteins are necessary to maintain the structure that holds epithelial cells tightly together.
41 citations,
July 2016 in “Radiation Research” Radiation damages salivary glands by harming blood vessels, but antioxidants might help protect them.
January 2022 in “Stem cell biology and regenerative medicine” iPSCs could help develop treatments for hair loss.
74 citations,
June 2018 in “Cell death and disease” Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.
1 citations,
November 2023 in “iScience” A protein called desmoglein 3 is important for keeping hair follicle stem cells inactive and helps in their regeneration.
April 2018 in “Journal of Investigative Dermatology” Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.
July 2021 in “International Ophthalmology” Female hair loss patients more likely to have dry eye and gland issues.
22 citations,
October 2018 in “Aesthetic Plastic Surgery” Understanding hair follicle biology and stem cell control could lead to new hair loss treatments.
September 2023 in “Medical and Clinical Case Reports” People with Alopecia Areata often have thyroid problems like Hashimoto thyroiditis and hypothyroidism.
129 citations,
January 2007 in “Otology & Neurotology” Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.
72 citations,
November 2012 in “PloS one” The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.
40 citations,
April 2014 in “Genes & Development” Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.
34 citations,
January 2008 in “International Review of Neurobiology” Epilepsy and certain epilepsy drugs can lead to reproductive problems in women, but changing medication might improve these issues.
33 citations,
December 2012 in “NMR in Biomedicine” Microencapsulation helps protect and track therapeutic cells, showing promise for treating various diseases, but more work is needed to improve the technology.