The Role of Vimentin in Tissue Repair and Cell Growth

    January 2023 in “ Åbo Akademi University Research Portal ”
    Mohanasundaram, Ponnuswamy
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    TLDR Vimentin is crucial for wound healing, cell growth, and managing immune responses.
    The study explored the role of vimentin in epithelial mesenchymal transitions (EMT) during wound healing, cell growth, and autoimmunity. In Vim-/- mice, the absence of vimentin led to delayed wound healing due to impaired EMT signaling, keratinocyte migration, fibroblast proliferation, and collagen deposition. Vimentin was found to influence mTOR signaling by modulating Rag GTPase activity, affecting cell size and autophagy. Additionally, vimentin expression increased in regulatory Treg cells, which manage autoimmune responses, through TGF-β1 mediation. The research highlighted new roles for vimentin in tissue repair and cellular growth.
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