Neuropharmacological Profile of Eclipta Alba (Linn.) Hassk

In the 2005 study, researchers examined the neuropharmacological effects of Eclipta alba on rats, using aqueous and hydroalcoholic extracts, as well as a hydrolyzed fraction of the plant. The study revealed that the aqueous extract at a dose of 300 mg/kg and the hydrolyzed fraction at 30 mg/kg exhibited nootropic activity, enhancing learning and memory. These extracts also provided significant protection against stress-induced gastric ulcers and normalized white blood cell counts in a leukocytosis model. The hydroalcoholic extract did not show significant neuropharmacological effects except in the leukocytosis model. The extracts were deemed safe up to a dose of 800 mg/kg, as they did not significantly alter locomotor activity or motor coordination, nor did they demonstrate anxiolytic properties in behavioral tests. Diazepam, used as a positive control, did show anxiolytic activity. Each treatment group in the study consisted of six rats (n=6), indicating a relatively small sample size.