April 2019 in “Journal of Investigative Dermatology” This study suggests that dietary grape powder may reduce the severity of atopic dermatitis in a mouse model, highlighting its potential in both prevention and intervention settings.
This source reviews advancements in microneedle-based cosmeceutical delivery, discussing new technologies and highlighting a burgeoning area of research involving microneedling combined with stem cell delivery for anti-aging, without finding measurable changes in skin barrier function or appearance during the study period.
January 2012 in “Durham e-Theses (Durham University)” This study found that knock-down of keratin 15 in various cell lines affected cell spreading, morphology, migration, differentiation, and proliferation, suggesting its role in maintaining the stem cell nature of keratinocytes.
January 2020 in “Medpulse International Journal of General Medicine” This study observed that trichoscopic patterns, such as yellow dots and honey comb patterns, correlate with the severity of androgenetic alopecia in Indian patients, highlighting trichoscopy's diagnostic and prognostic value.
This dissertation reported that the loss of Ovol2 impairs hair follicle regeneration and wound repair in mice, highlighting its role in regulating directional migration of epithelial cells.
This study identified a genetic locus associated with rhabdomyosarcoma susceptibility in mice and found that specific differentiation markers are linked to the regression of basal cell carcinoma.
75 citations
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November 1965 in “Textile research journal” This study found that papain/bisulfite disintegrates human hair cuticles by dissolving the endocuticle, potentially accelerated by ethanol's removal of cell membrane material.
1057 citations
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November 2011 in “Annals of Biomedical Engineering” This review discusses the applications of low level laser therapy (LLLT) in wound healing, pain reduction, and treating various conditions, but reports no new clinical results; the authors highlight the need for randomized controlled trials for serious diseases.
59 citations
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January 2015 in “Nanoscale” In this study, polymeric micelles containing retinoic acid were found to improve targeted delivery to hair follicle structures in human skin more efficiently than a marketed retinoic acid gel, suggesting potentially safer and more effective acne treatment.
36 citations
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February 2018 in “British Journal of Dermatology” In this study, researchers found that eccrine sweat glands in human scalp skin are morphologically integrated into the pilosebaceous unit, suggesting they form a common homeostatic tissue environment with adjacent structures.
28 citations
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November 2018 in “Journal of structural biology” This study found statistically significant patterns in hair morphology and ultrastructure linked to biogeographic ancestry among European, African, and East Asian populations.
19 citations
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February 2008 in “Facial Plastic Surgery” This article reviews various reconstructive surgery techniques for scalp wounds and emphasizes factors affecting aesthetic outcomes, but it presents no new clinical findings.
7 citations
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January 2016 in “Methods in molecular biology” This study describes the process of isolating and analyzing multipotent stem cells from mouse hair follicles for potential use in tissue engineering and regenerative medicine.
6 citations
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March 2016 in “PLoS ONE” This study characterized hair from a patient with a ribosomopathy and identified distinct differences, including reduced hair thickness and lipid content, compared to family members.
This source reports that modern hair transplant techniques, including follicular unit grafting, can create natural-looking results and are increasingly used beyond male pattern baldness to treat areas like eyebrows and scars, while even some controversial indications are being explored.
January 2026 in “Scientific Reports” In this study, researchers found that sesamin, a component of sesamum, modulated the AR-MAPK-Wnt signaling pathway in DHT-stimulated HaCaT keratinocytes, demonstrating potential multi-target activity against molecular events in androgenetic alopecia.
5 citations
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February 2018 in “Experimental Dermatology” This study describes a method inspired by hair transplantation techniques to efficiently isolate eccrine sweat glands from human scalp hair grafts, potentially facilitating further research into their function.
341 citations
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November 2009 in “The FASEB Journal” This article reviews the multifunctional roles of calreticulin outside the ER and highlights its impact on wound healing in animal models, but reports no new clinical results.
421 citations
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January 2015 in “Chemical Society Reviews” This review discusses recent advances in surface modification and endothelialization of biomaterials for vascular grafts, highlighting promising methods like gene engineering and targeting ligand immobilization to improve clinical outcomes.
157 citations
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May 2021 in “Endocrine Reviews” This review discusses recent advancements in understanding and managing congenital adrenal hyperplasia, including improvements in screening, diagnostics, and potential genetic and cell-based treatments, but reports no new clinical findings.
82 citations
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May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” The study reported that combining the Follicular Closing Technique with the Franz diffusion cell is a valuable method for investigating follicular caffeine penetration in vitro, though kinetics differ from in vivo results.
57 citations
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February 2013 in “Journal of Dermatological Science” This article reviews methods to enhance epithelial–mesenchymal interactions for hair follicle bioengineering but does not present new experimental results; it emphasizes optimizing combinations for successful regeneration.
51 citations
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March 2019 in “Journal of cellular physiology” This review discusses the use of platelet lysate and its growth factors in treating diseases and regenerative medicine but reports no new clinical findings.
47 citations
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February 2021 in “Pharmacological research” This review discusses the potential of endogenic and exogenous exosomes in dermatology and cutaneous aesthetics, highlighting their capacity to repair and rejuvenate skin tissue, but reports no new experimental results.
47 citations
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July 2014 in “European Journal of Pharmaceutics and Biopharmaceutics” This study concluded that polymeric nanoparticles effectively targeted hair follicles for drug delivery, but the organogel formulation did not enhance their penetration into the hair shaft.
46 citations
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January 2020 in “Theranostics” This study demonstrated that OSA hydrogels enhanced the stability and retention of dermal papilla-derived extracellular vesicles, which significantly improved hair regeneration in both cultured human hair and a mouse depilation model.
43 citations
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November 2018 in “Nature Communications” This genome-wide association study identified 20 genetic signals at 15 risk loci related to severe acne, revealing new insights into its genetic predisposition, particularly affecting skin structure and maintenance.
9 citations
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February 2022 in “Nature communications” This study identified KRT82 as a significant Alopecia Areata risk gene, finding that rare damaging variants are linked to elevated immune cell infiltration around hair follicles in affected individuals.
9 citations
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March 2013 in “Expert opinion on biological therapy” This article reviews recent research on adult epidermal stem cells, discussing their properties and potential for reprogramming into patient-specific therapies, and emphasizes the need for further development while minimizing cancer risk.
9 citations
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November 2008 in “Facial Plastic Surgery” This article reviews techniques for repairing scalp deformities and concludes that combining older methods with modern hair restoration allows for satisfactory treatment of large scarred areas.