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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

New information shows Valproate may protect the brain and reduce breathing failure risk but can cause liver damage and other side effects, with genetics affecting dosage needs.

The document concludes that various findings in rheumatology offer insights into disease severity, treatment responses, and potential risks in medication, with some limitations due to unspecified participant numbers.

EtG in hair can help detect alcohol use but may be inaccurate in people with certain health conditions.

The traditional herbal formulas Yongdamsagan-Tang and Paljung-san, along with the drug finasteride, can reduce inflammation and may work together without affecting each other's effectiveness against benign prostatic hyperplasia.

Finasteride may lower cholesterol and slow heart disease progression.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.

Food intake, not genetics, affects how the body processes tadalafil and finasteride.

Topical finasteride at 0.25% is effective and has fewer side effects than oral finasteride for hair loss.

Genetic variants can affect valproic acid's effectiveness, side effects, and levels in epilepsy treatment.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

New compounds may help treat prostate cancer by reducing cell growth.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Computational methods can speed up and improve the development and safety of herbal drugs.

Father's finasteride use may affect son's fertility and testicular function.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

More research is needed to understand how testosterone is maintained in adult males.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Researchers found potential urine markers for polycystic ovary syndrome, including testosterone-glucuronide and 11α-hydroxyprogesterone, which may help diagnose the condition.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Glutathione helps Arabidopsis roots adapt to low phosphate by regulating a specific growth pathway.

Finasteride helps hair growth and prostate issues but may cause sexual side effects and increase tumor risk.