EtG Quantification in Hair and Different Reference Cut-Offs in Relation to Various Pathologies: A Scoping Review

    November 2022 in “ Toxics ”
    Valentina Triolo, Mario Spanò, Roberto Buscemi, Simona Gioè, Ginevra Malta, Marija Čaplinskienė, Fabio Vaiano, Elisabetta Bertol, Stefania Zerbo, Giuseppe Albano, Antonina Argo
    Studysummary This review describes how liver and kidney diseases and diabetes may affect ethyl glucuronide levels in hair, impacting forensic and clinical interpretations, but reports no new experimental results. Our plain-language summary of this paper — not a Tressless recommendation.
    This scoping review explores the use of ethyl glucuronide (EtG) in hair as a marker for alcohol consumption, particularly in individuals with liver and kidney diseases, diabetes, and transplant recipients. It highlights that these conditions can affect EtG levels, leading to potential false positives or negatives. Renal dysfunction can cause high EtG concentrations due to delayed excretion, complicating alcohol consumption interpretation. The review emphasizes the need for careful consideration of these pathologies and calls for further research to refine EtG testing methods and establish accurate cut-off levels. Despite limitations, hair EtG testing can improve alcohol consumption detection, especially in liver disease patients, with varying sensitivity and specificity based on disease severity and cut-off levels.
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