Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride

October 2023 in “ Journal of personalized medicine ”

Gonzalo Villapalos‐García, Pablo Zubiaur, Cristina Marián-Revilla, Paula Soria‐Chacartegui, Marcos Navares‐Gómez, Gina Mejía‐Abril, Alexander Rodríguez-López, Eva González-Iglesias, Samuel Martı́n-Vı́lchez, Manuel Román, Dolores Ochoa, Francisco Abad‐Santos

tadalafil finasteride pharmacokinetic variability food administration drug absorption metabolism area under the curve maximum plasma concentration time to reach Cmax Cialis Propecia

Studysummary In this study, researchers investigated genetic variants in pharmacogenes affecting tadalafil and finasteride pharmacokinetics, finding fed volunteers had higher drug exposure than fasting individuals, but genetic variation did not significantly impact pharmacokinetics after correcting for multiple comparisons.

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