Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride

    October 2023 in “ Journal of personalized medicine ”
    Gonzalo Villapalos‐García, Pablo Zubiaur, Cristina Marián-Revilla … Francisco Abad‐Santos
    Studysummary In this study, researchers investigated genetic variants in pharmacogenes affecting tadalafil and finasteride pharmacokinetics, finding fed volunteers had higher drug exposure than fasting individuals, but genetic variation did not significantly impact pharmacokinetics after correcting for multiple comparisons.
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    Research cited in this study 5

    1. Evidence for the Efficacy and Safety of Tadalafil and Finasteride in Combination for the Treatment of Lower Urinary Tract Symptoms and Erectile Dysfunction in Men with Benign Prostatic Hyperplasia Therapeutic advances in urology · 2016
    2. Finasteride Drugs · 1999
    3. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride Clinical Pharmacokinectics · 1996
    4. Finasteride Drugs · 1993
    5. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992

    Related research 1

    1. Bioequivalent Assessment of Finasteride Granules in Chinese Healthy Volunteers Chinese Journal of Drug Application and Monitoring · 2009