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In this study, researchers investigated genetic variants in pharmacogenes affecting tadalafil and finasteride pharmacokinetics, finding fed volunteers had higher drug exposure than fasting individuals, but genetic variation did not significantly impact pharmacokinetics after correcting for multiple comparisons.

This study demonstrates that bioequivalence for proposed 50-mg ritlecitinib capsules versus clinical 100-mg capsules can be supported using a PBPK model-based biowaiver, achieving over 90% probability of success.

This study found that a testosterone patch and gel showed bioequivalent testosterone levels in hypogonadal men, but the patch mimicked a natural circadian profile, while the gel resulted in higher dihydrotestosterone levels.

This review discusses the role of androgen therapy and neurosteroids in cerebrovascular health, highlighting the potential risks and benefits and the importance of pharmacogenetic testing, but reports no new experimental results.

This study established a simple and accurate LC-MS method for quantifying vinflunine in Beagle dog plasma, supporting pharmacokinetic research in this context.