Original Research—Endocrinology: Comparison of the Steady-State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men

    February 2005 in “ ˜The œjournal of sexual medicine ”
    Norman A. Mazer, Damon A. Bell, Jingyang Wu, Jerome S. Fischer, Michael Cosgrove, Barbara Eilers
    Image of study
    TLDR The testosterone patch and gel are both effective, but they have different absorption patterns and effects on hormone levels.
    The study compared the pharmacokinetics, metabolism, and variability of a testosterone patch versus a testosterone gel in 28 hypogonadal men over 14 days. The patch mimicked the circadian testosterone pattern, while the gel produced a flatter profile with variable peaks. Both treatments were bioequivalent in terms of average and maximum testosterone levels, but the patch had lower minimum levels. The gel resulted in 2 to 3-fold higher dihydrotestosterone levels. Variability in peak times was much higher for the gel. Both treatments were well tolerated, with the patch adhering well. These results highlighted different absorption mechanisms and provided insights for selecting testosterone therapies.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community 5 months of nuking T, 2 months of minoxidil

      in Transgender  489 upvotes 7 months ago
      The user transitioned from finasteride to Cyproterone and started using Minoxidil, resulting in healthier hair and regrowth. They plan to wean off Minoxidil in a year, depending on regrowth.

      community New Latanoprost-Based Formula Used by Hollywood Celebrities

      in Treatment  26 upvotes 2 years ago
      A new Latanoprost-based formula used by Hollywood celebrities to treat hair loss, with the formula containing minoxidil, tretinoin, melatonin, azelaic acid, zinc thymulin, vitamin B6, sandalore and methyl vanillate. It also mentions the potential of offering a combined sublingual minoxidil/oral dutasteride option in the future.

      community Topical minoxidil 3 months results

      in Progress Pictures  624 upvotes 2 years ago
      This conversation is about a user named "mr_mime125" who experienced results from using topical finasteride (0.1%) and minoxidil (5%) solution 1.5 ml twice a day for the first two months followed by just minoxidil (5%) 1 ml once a day in the last month, resulting in a drastic improvement to their hairline. Other users discussed their progress while asking questions and offering encouragement.

      community Anyone else super depressed cause of hairloss?

      in Finasteride/Dutasteride  185 upvotes 1 month ago
      A 20-year-old is dealing with hair loss, using finasteride and oral minoxidil, and considering dutasteride. Others suggest treatments like dutasteride, hair transplants, therapy, and lifestyle changes to boost confidence and mental health.

      community What was your “f*ck I’m balding” story?

      in Chat  178 upvotes 1 year ago
      User noticed thinning hair at 18-19, started finasteride at 22 and minoxidil at 24, with positive results. Others shared hair loss experiences and treatments, including finasteride, minoxidil, and hair transplants.

    Similar Research

    5 / 1000+ results