Cardiovascular Risks and Elevation of Serum DHT Vary by Route of Testosterone Administration: A Systematic Review and Meta-Analysis

    November 2014 in “ BMC Medicine ”
    Stephen E. Borst, Jonathan J. Shuster, Baiming Zou … Joshua F. Yarrow
    Studysummary This research observed that oral testosterone replacement therapy significantly increases cardiovascular risk, while effects of injected or transdermal therapy on cardiovascular risk were not significant, prompting further investigation into these methods.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on bmcmedicine.biomedcentral.com →
    Discuss this study in the Community →

    Research cited in this study 8

    1. Testosterone, Dihydrotestosterone, and Incident Cardiovascular Disease and Mortality in the Cardiovascular Health Study ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2014
    2. Invalidation of a Commercially Available Human 5α-Dihydrotestosterone Immunoassay Steroids · 2013
    3. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    4. Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production JAMA · 2012
    5. Intracrine and Myotrophic Roles of 5α-Reductase and Androgens Medicine and science in sports and exercise · 2011
    6. Steady-State Pharmacokinetics of Oral Testosterone Undecanoate with Concomitant Inhibition of 5α-Reductase by Finasteride International Journal of Andrology · 2010
    7. Original Research—Endocrinology: Comparison of the Steady-State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men ˜The œjournal of sexual medicine · 2005
    8. Exogenous Testosterone or Testosterone with Finasteride Increases Bone Mineral Density in Older Men with Low Serum Testosterone The Journal of Clinical Endocrinology and Metabolism · 2004

    Related research 1

    1. Testosterone Therapy for Osteoporosis in Men Elsevier eBooks · 2010