Invalidation of a Commercially Available Human 5α-Dihydrotestosterone Immunoassay

    September 2013 in “ Steroids ”
    Joshua F. Yarrow, Darren T. Beck, Christine F. Conover … Stephen E. Borst
    Studysummary This study found that a commonly-used DHT enzyme immunoassay shows significant cross-reactivity with testosterone, leading to inaccurate DHT measurements compared to a gold-standard LC–MS/MS method.
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    Research cited in this study 6

    1. Intracrine and Myotrophic Roles of 5α-Reductase and Androgens Medicine and science in sports and exercise · 2011
    2. Anabolic Effects of Testosterone Are Preserved During Inhibition of 5α-Reductase Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism · 2007
    3. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    4. Exogenous Testosterone or Testosterone with Finasteride Increases Bone Mineral Density in Older Men with Low Serum Testosterone The Journal of Clinical Endocrinology and Metabolism · 2004
    5. 5alpha-Reductase: History and Clinical Importance PubMed · 2004
    6. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003