134 citations
,
March 2015 in “Clinical Endocrinology”
This study introduced a validated LC-MS/MS-based method for profiling long-term steroid concentrations in human scalp hair, offering potential applications in endocrinology research.
30 citations
,
July 2023 in “Clinical Chemistry and Laboratory Medicine (CCLM)”
In this study, researchers developed an LC-MS/MS method to accurately quantify cortisone and cortisol levels in human scalp hair, finding that concentrations decrease predictably along the hair shaft, which could assist in identifying abnormal glucocorticoid exposure.
9 citations
,
November 2022 in “International Journal of Molecular Sciences”
This study found that LC-MS/MS assays provided more reliable and precise steroid measurements in human serum compared to traditional immunoassays, particularly at lower concentrations.
9 citations
,
January 2017 in “Ginekologia Polska”
This study found that the total testosterone/dihydrotestosterone ratio correlates with a negative metabolic profile in both women with PCOS and healthy women.
Finasteride and Nizoral shampoo with Ketoconazole are used for hair loss treatment. Liquid Chromatography–Mass Spectrometry (LC-MS) is recommended over Enzyme-Linked Immunosorbent Assay (ELISA) for more accurate DHT testing.
The conversation provides a guide on using finasteride for hair loss, suggesting to start with a quarter of a 1mg pill daily after ensuring estradiol levels are within a specific range, and potentially increasing the dose if no side effects occur. It also recommends supplements like DIM, Calcium d-glucarate, and Zinc to manage high estradiol levels and side effects from finasteride.
The user has high DHT levels despite using dutasteride, which may not be effective due to potential damage or spoilage. They are considering a hair transplant if DHT levels don't decrease after two years.
Finasteride's effectiveness may be reduced due to heat exposure, affecting DHT levels. Testing methods and medication storage conditions are likely factors in the unchanged DHT levels.
A user experienced accelerated hairline recession after adding dutasteride to their regimen of topical finasteride and minoxidil, despite reduced hair shedding. They were informed that ELISA testing for DHT levels can be highly inaccurate.