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GlossaryHypogonadism

condition where sex glands produce insufficient hormones

Hypogonadism is a medical condition where the body's sex glands, the testes in men and the ovaries in women, produce little or no hormones. This can lead to various symptoms such as reduced libido, infertility, and in some cases, hair loss. It can be caused by genetic factors, injury, or certain medical conditions, and often requires hormone replacement therapy for management.

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research Original Research—Endocrinology: Comparison of the Steady-State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men

38 citations, February 2005 in “The journal of sexual medicine”

The testosterone patch and gel are both effective, but they have different absorption patterns and effects on hormone levels.

research Oral Testosterone With and Without Concomitant Inhibition of 5α-Reductase by Dutasteride in Hypogonadal Men for 28 Days

11 citations, December 2010 in “The Journal of Urology”

Taking oral testosterone with or without dutasteride increases testosterone levels and could be an effective treatment for low testosterone.

research Clinical Improvements in Erectile Function and Mood in Hypogonadal Men Treated with 4.5% Nasal Testosterone Gel (Natesto)

February 2018 in “The Journal of Sexual Medicine”

Natesto nasal gel improves erectile function and mood in men with low testosterone within 30 days.

research New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men

14 citations, January 2018 in “Advances in Clinical Chemistry”

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

research The Five-Year Effects of Testosterone Replacement Therapy on Lipid Profile and Glucose Tolerance Among Hypogonadal Men in Japan: A Case Control Study

6 citations, January 2020 in “The Aging Male”

Testosterone replacement therapy improved blood sugar and fat levels without raising prostate cancer risk in Japanese men with low testosterone.

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community Got Blood Work Lab Results for hormones. Need some help analyzing hormone values for Fin

in Finasteride/Dutasteride 8 upvotes 2 years ago

The user got blood work to check hormone levels before starting Finasteride for hair loss and is seeking advice on interpreting the results. They are considering hormone levels in relation to potential side effects of Finasteride.

community Is it possible for androgenic alopecia to begin at early adolescent years?

in Chat 70 upvotes 1 year ago

Hair loss can begin in early adolescence and cause mental anguish. Treatments mentioned include eating cruciferous vegetables, engaging in physical activity, and maintaining scalp hygiene.

community Debunking the "Adverse metabolic consequences of dutasteride"

in Research/Science 40 upvotes 3 years ago

Dutasteride is more effective than finasteride, has neuroprotective benefits, and may prevent acne. Despite initial concerns about metabolic effects, further research suggests it is safe for most users, especially if not hypogonadal.

community Does age play a role in how you respond to 5AR inhibitors? (finasteride/dutasteride)

in Research/Science 24 upvotes 8 months ago

The conversation discusses whether age affects the side effects and effectiveness of hair loss treatments like finasteride and dutasteride. Some believe early treatment yields better results, while others mention varied outcomes across ages and personal regrowth experiences without a clear consensus on age impact.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 449 upvotes 4 months ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

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