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Testosterone is crucial for development, growth, and various body functions in mammals.

Low level laser therapy works best for hair loss, followed by PRP, finasteride, and minoxidil.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

JAK inhibitors are effective in treating various immune-related diseases, not just rheumatoid arthritis.

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

Platelet Rich Plasma (PRP) shows promise for tissue repair and immune response, but more research is needed to fully understand it and optimize its use.

Histone demethylases play a key role in the development of many diseases and may be targets for treatment.

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

Liquid nitrogen spray caused a temporary, harmless swelling under the skin in an elderly woman.

Acne is caused by multiple factors including oil production, bacteria, inflammation, and possibly diet and environment.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Effective hair loss treatment in women requires correct diagnosis and can include medications like minoxidil, antiandrogens, and treatments for underlying conditions like PCOS.

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

Human liver cells stick to hair protein materials mainly through the liver's asialoglycoprotein receptor.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

Human hair follicle dermal cells can effectively replace other cells in engineered skin.

Sex hormones affect brain injury differently in males and females.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.