Ovarian SAHA Syndrome Is Associated With a More Insulin-Resistant Profile and Represents an Independent Risk Factor for Glucose Abnormalities in Women With Polycystic Ovary Syndrome: A Prospective Controlled Study

In 2013, a prospective controlled study involving 316 women with PCOS, of whom 56 had ovarian SAHA syndrome, and 102 healthy controls, found that ovarian SAHA syndrome is associated with a more insulin-resistant profile and is an independent risk factor for glucose abnormalities in women with PCOS. The study showed that women with SAHA had higher HOMA-IR scores and lower MATSUDA indices, indicating lower insulin sensitivity. The presence of SAHA was also linked to a more severe PCOS phenotype. The study highlighted the importance of early recognition of SAHA in women with PCOS for the early diagnosis and monitoring of metabolic abnormalities, suggesting that these women may benefit from lifestyle changes and insulin sensitizers like metformin to manage their condition and reduce the risk of developing type 2 diabetes. However, further research is needed to explore the potential cardiovascular risks associated with this insulin-resistant profile.