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Stem cell self-renewal is complex and needs more research for full understanding.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

Cathepsin L is essential for normal hair growth and development.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Higher levels of unbound testosterone are linked to increased insulin resistance, especially in women with polycystic ovary syndrome.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.

Fat cells in the skin help start healing and form important repair cells after injury.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

JAK inhibitors help with skin conditions but need more research on dosing and safety.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Hair loss linked to higher heart disease risk in both men and women.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Lowering testosterone speeds up wound healing in male mice.

Overexpressing Dsg3 in mice skin causes excessive cell growth and abnormal skin development.

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

Correct skin biopsy techniques are crucial to avoid misdiagnosis of skin diseases.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

A mother's PPARγ is crucial for preventing harmful milk that can cause inflammation and growth problems in babies.

People with alopecia areata often have other health issues like skin diseases, metabolic syndrome, stomach infections, lupus, anemia, thyroid problems, mental health issues, vitamin D deficiency, and hearing and eye problems.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

There are many treatments for permanent hair loss disorders, but their effectiveness varies and there's no clear best option.