research Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis
Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.
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60-90 / 1000+ results research The Thrill of Scientific Discovery and Leadership with My Group
The author felt excited and honored to receive the 2016 Early Career Life Scientist Award.
research Neoplasms Bypass Immune Evasion via Hair Follicle Residence
Neoplasms hide in hair follicles to avoid the immune system.
research The Extracellular Matrix Dictates Regional Competence for Tumor Initiation
The extracellular matrix affects where tumors can start in the body.
research Montagna Symposium 2014: Skin Aging - Molecular Mechanisms and Tissue Consequences
The symposium concluded that understanding the molecular mechanisms of skin aging could lead to better clinical practices and treatments.
research Targeting the Hippo/YAP/TAZ Signalling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers
Blocking YAP/TAZ could be a new way to treat skin cancer.
research An In Situ Chemotherapy Drug Combined with Immune Checkpoint Inhibitor for Chemoimmunotherapy
Combining specific nanoparticles with immune therapy significantly improves cancer treatment.
research Abstracts
New treatments and diagnostic methods for various animal skin conditions showed promising results.
research TRP Channels in Skin Biology and Pathophysiology
TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.
research A Slow-Cycling LGR5 Tumor Population Mediates Basal Cell Carcinoma Relapse After Therapy
A small group of slow-growing cells causes basal cell carcinoma to return after treatment.
research The Application Prospects of Honokiol in Dermatology
Honokiol from Magnolia plants may be beneficial for treating various skin conditions and promoting hair growth.
research Case Number 19 of Perforating Necrobiosis Lipoidica Worldwide
The document reports the first case of a rare skin condition in Colombia, the 19th case worldwide.
research First-In-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.
research The Stem Cell Niche in Regenerative Medicine
Targeting and modifying the stem cell niche can improve regenerative therapies.
research The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia
Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.
research Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers
The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.
research Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One
Adding a second method to PROTACs could improve cancer treatment.
research Advances in Stem Cell-Based Therapy for Hair Loss
Stem cell therapies show promise for treating hair loss, but more research is needed to understand their safety and effectiveness.
research Lgr6+ Stem Cells and Their Progeny in Mouse Epidermis Under Regimens of Exogenous Skin Carcinogenesis, and Their Absence in Ensuing Skin Tumors
UV exposure reduces Lgr6+ stem cells in mouse skin and they don't significantly contribute to skin cancer development.
research Polycystic Ovary Syndrome and Iron Overload: Biochemical Link and Underlying Mechanisms with Potential Novel Therapeutic Avenues
Polycystic ovary syndrome and iron overload share similar symptoms and can be potentially treated with blood removal, diet changes, and probiotics.
research Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies
Nanoformulations improve luteolin's effectiveness as a cancer treatment.
research Blank Spots in the Map of Human Skin: The Challenge for Xenotransplantation
Human skin xenografting could improve our understanding of skin development, renewal, and healing.
research Keratinocyte Stem Cells: Role in Aging
Aging reduces skin stem cell function, leading to changes like hair loss and slower wound healing.
research The Use of Trilostane for the Treatment of Alopecia X in Alaskan Malamutes
Trilostane effectively treated hair loss in Alaskan Malamutes with no adverse effects.
research Comment on Malloy (2008): James Watson Tells the Inconvenient Truth and Faces the Consequences
The conclusion suggests a new treatment for infantile hemangiomas and a potential target for hair loss treatment.
research The Psychological Effects of Androgenetic Alopecia in Men
Hair loss can cause low self-esteem, anxiety, and depression in men.
research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management
Restoring hair bulb immune privilege is crucial for managing alopecia areata.
research Doxil (Caelyx): An Exploratory Study with Pharmacokinetics in Patients with Hormone-Refractory Prostate Cancer
Doxil showed some effectiveness against advanced prostate cancer but caused severe side effects at higher doses.
research The Dihydrotestosterone Hypothesis of Prostate Cancer and Its Therapeutic Implications
The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.
research The Dynamic Duo: Niche and Stem Cell Interdependency
Stem cells and their surrounding environment in hair follicles work closely together, affecting hair growth and having implications for cancer and tissue regeneration.