Case Number 19 of Perforating Necrobiosis Lipoidica Worldwide

The document described the 19th reported case of perforating necrobiosis lipoidica (PNL) worldwide and the first in Colombia. PNL is a rare condition seen in diabetic patients, characterized by the elimination of necrobiotic collagen through the epidermis, leading to distinctive skin lesions. The case involved a 49-year-old female with poorly controlled diabetes, presenting with multiple plaques on her body. Despite treatment with tacrolimus ointment, there was minimal improvement, and the patient was referred for better metabolic control. Histological examination confirmed the diagnosis of PNL, showing degenerated collagen being expelled through hair follicles and palisaded granulomas. The document emphasized the chronic nature of PNL, its association with diabetes, and the generally poor response to treatment.