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This study suggests that increased amounts of less stable disulfide conformers in hair shafts may be linked to the brittleness observed in trichothiodystrophy.

This study found that a new method using enzymatic laundry powder effectively extracts DNA from hair shafts, showing promise for genome-wide DNA analyses.

This study found that cystatin M/E strongly inhibits human cathepsin V and cathepsin L via distinct non-overlapping sites, suggesting an important role in human epidermal differentiation and hair follicle morphogenesis.

In this study, researchers developed a non-invasive, partially automated protocol for extracting DNA from marmoset hair follicles, resulting in high-quality whole genome sequencing with low chimerism levels, making it a reliable method compared to blood DNA sequencing in these primates.

This study found that type II keratins in proliferating epithelial tissues are phosphorylated at a conserved motif during mitosis and stress, impacting keratin solubilization and reorganization.

This study developed a partially automated protocol utilizing hair follicles for DNA extraction in marmosets, achieving reliable whole genome sequencing with low chimerism, offering an efficient alternative to blood for genetic studies in non-human primates.

This study found that specific enzymes could be detected in fresh hair sheath cells, with most remaining detectable in older cells, except for Adenylate kinase and Esterase D.

This study proposes a new method to selectively isolate keratin-associated proteins and keratin from human hair, suggesting that KAPs may support keratin fibers in hair structure.

This study demonstrates a sample preparation method for wool follicles that allows for clear keratin labeling and ultrastructural preservation in microscopy, reducing common artefacts from conventional fixation techniques.

This study found that a single dose of TRP significantly reduced the number of UV-B-induced actinic keratosis lesions in a mouse model and was associated with improved skin histology and minimal side effects.

This study found that trichothiodystrophic hair shows reduced and disoriented protein deposition in follicles, with both the cuticle and cortex affected, providing localized structural insights into keratin abnormalities.

The study found that sonication washing of hair roots with fewer than 50 visible nuclei could reduce the number of nuclei available for DNA extraction and STR typing, suggesting that for laboratories focused on nuDNA analysis, a gentler washing method might be adequate.

This study successfully synthesized acetyl tetrapeptide-3 on a laboratory scale with over 56% yield and 100% purity, supporting its use in developing hair loss and scalp care products.

This study found that using a bicomponent reduction system with TGA and DTDG for hair straightening limited hair damage by forming only thiol groups, while a TGA-only system formed more damaging mixed disulfide groups.

This study found that Mf-rich-fiber in human hair underwent significantly greater degradation by proteases than Ma-rich-fiber, especially when treated with Proteinase K.

In this study, chemical treatments during permanent hair straightening were found to randomize proteins in the cortex, aiding in the reconnection of disulfide bonds during oxidation.

This study observed that repeated perm treatments decrease disulfide bonds in hair due to their conversion largely into cysteic acid, affecting the waving efficiency depending on the reduction agent used.

The study found that a modified two-step enzyme digestion method was an efficient and rapid technique for isolating human axillary dermal papilla cells from a few specimens.

This study observed that different alkaline buffers had a significant impact on the volume of liquid consumed by fall armyworm larvae, emphasizing the importance of measuring imbibed volumes to reduce dose errors in bioassays.

This study identified a human sequence likely coding for a new ultra-high sulphur protein, which may aid in understanding hair differentiation and the molecular basis of human trichothiodystrophy.

This review discusses the progress and challenges of targeted protein degradation therapies, highlighting the increasing number of degraders in cancer clinical trials and the limited diversity in targeted proteins, primarily focusing on those employing CRL4^CRBN as the E3 ligase.

This study found that electrophoretic keratin typing of head hair can identify specific polypeptide patterns, suggesting potential applications in genetic and forensic investigations.

In this case report, a 20-year-old male with tricho-rhino-phalangeal syndrome was found to have a de novo frameshift mutation in the TRPS1 gene, highlighting the challenges in diagnosing this rare disorder.

This study reported successful recovery of biologically active recombinant murine Wnt3a without detergent, suggesting usefulness for structure-activity studies avoiding detergent-related issues.

In this study, hair shafts from trichothiodystrophy patients with ERCC2 mutations revealed abnormal cuticle structures and protein imbalances compared to normal hair shafts.

This study found that TSA restored the hair-inductive capacity of skin-derived precursors in mice by enhancing BMP gene expression and signaling through histone acetylation.

This study demonstrated that keratin can be effectively extracted from wool using alkaline solutions and that the extracted keratin maintains reactivity similar to that from other low-value sources like cattle hair.

This case study identified Trichophyton rubrum as the cause of trichophytia profunda acuta in a patient using nested PCR, suggesting an alternative diagnostic approach when KOH tests and cultures fail.