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The authors concluded that newly synthesized N-acyl-L-tryptophanyl-isoleucine amides showed high anxiolytic activity in animal models, comparable to diazepam, through interaction with the TSPO receptor.

This study suggests that skin tumor cells in tuberous sclerosis complex may promote hamartoma morphogenesis by expressing and releasing higher levels of cathepsin B.

This study found that trichothiodystrophy can be diagnosed prenatally in the second trimester using an endoscopically-guided fetal eyebrow biopsy, with sulfur content analysis being the most reliable test.

This report describes a new case of isolated trichothiodystrophy with characteristic brittle hair and suggests a simplified classification scheme for understanding sulfur-deficient hair disorders.

TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.

In this study, applying the microbial enzyme transglutaminase from Streptomyces mobaraensis to damaged hair increased its tensile strength by 15.64%, suggesting potential benefits in repairing shampoo-induced damage and improving hair luster.

This study reports that citrulline, uniquely found in the inner root sheath of hair follicles, can be specifically detected with the carbamido diacetyl reaction, resulting in a bright orange color.

In this report, an 18-year-old female with trichotillomania was successfully treated using the glutamate modulator n-acetylcysteine.

In this study, autophagy was commonly observed during keratinization in neonate rat hair follicles, suggesting lysosomal proteases and cytoplasmic enzymes may coordinate in hair follicle cell differentiation.

This review highlights the role of matriptase in epithelial differentiation and cancer, noting that unregulated matriptase expression can enhance cancer progression in animal models, but reports no new experimental data.

This case report describes a patient with eosinophilia-myalgia syndrome related to L-tryptophan use, detailing the specific symptoms and laboratory abnormalities observed.

This review examines the development and challenges of using PROTACs, a targeted protein degradation strategy, to treat cancer by degrading specific proteins like PARPs and GPX4, highlighting issues such as target diversification and bioavailability.

This study identified trichohyalin as an early differentiation marker in hair follicles, with potential structural roles related to alpha-helical formations, based on the partial characterization of its cDNA in sheep.

In this study, the researchers found that the absence of the NFI-C transcription factor delayed the hair growth cycle in mice by affecting key gene expressions and signaling pathways.

This study demonstrated that de novo designed bifunctional proteins can target and degrade BCL-xL, leading to cell apoptosis, suggesting a new approach to targeted protein degradation therapy.

This study suggests that extracting hair proteins at relatively high temperatures may enhance their hemostatic properties by altering their secondary structure and increasing the precipitation of soluble fibrinogen.

This study reports that using laser microdissection to isolate telogen hair follicles significantly improves DNA extraction efficiency for STR typing, reducing contamination from keratin.

Specific cross-linkages help make hair proteins stable and strong.

This study reports that a 190,000 molecular weight protein, identified as trichohyalin, may play a matrix role in the development of inner root sheaths in hair follicles.

This study found that a papain-containing cream had a significantly greater depilatory effect and altered skin morphology more than a papain-containing gel when applied to mice.

This study found that the PLEE method increased hair protein extraction efficiency threefold and that bleaching hair reduced the coverage of keratin and associated proteins, leading to poorer hair quality, though it did not affect the overall protein identification.

This study developed a new method using ultrahigh-power sonication and mass spectrometry to improve protein extraction from hair shafts, identifying 239 differentially expressed proteins related to fetal growth restriction, which were validated as potential noninvasive biomarkers for perinatal diagnostics.

This study found that reduced hair samples showed higher protease degradation than permed hair, which increased with repetitive perming, and degradation was influenced by the type of mercaptan used.

This study observed that cathepsin L and transglutaminase 3 colocalize in the human hair bulb and nail matrix, suggesting their involvement in terminal differentiation within these epidermal appendages.

This study found that the tetrazolium salt INT is the most effective for revealing dehydrogenase activity and certain histological structures in sheep and other mammals' skin.

Tiger tail banding and hair abnormalities are reliable indicators for diagnosing trichothiodystrophy.