TLDR Laser microdissection helps get DNA from single hair follicles for better forensic analysis.
The study explored the use of laser microdissection to isolate and extract DNA from single hair follicles, specifically targeting the bulb of telogen hairs, which are commonly found at crime scenes but are challenging for DNA extraction due to high keratin content. By using a Leica AS LMD, researchers were able to effectively separate the hair bulb from keratin, allowing for successful DNA typing through short tandem repeat (STR) profiling. This technique improved the ability to obtain genetic profiles from hair samples, enhancing forensic investigations.
11 citations
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March 2014 in “Journal of Investigative Dermatology” Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.
150 citations
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October 2010 in “The American Journal of Pathology” The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.
17 citations
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August 2019 in “Frontiers in Immunology” Non-invasive methods show promise for diagnosing skin diseases like psoriasis and lupus but need more research for regular use.
April 2021 in “Sohag Medical Journal” Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.
26 citations
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July 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects” The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.
