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Glossary Laser Capture Microdissection

technique using a laser to isolate specific cells from tissue

Laser Capture Microdissection (LCM) is a technique used to precisely isolate specific cells or regions from a tissue sample using a laser. This allows researchers to study the genetic material, proteins, or other cellular components of the selected cells without contamination from surrounding tissues, making it particularly useful in fields like cancer research and pathology.

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Research

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research Laser microdissection and DNA typing of cells from single hair follicles

45 citations , December 2004 in “Forensic Science International”

This study reports that using laser microdissection to isolate telogen hair follicles significantly improves DNA extraction efficiency for STR typing, reducing contamination from keratin.

research Laser capture microdissection as a method for investigating the human hair follicle microbiome reveals region-specific differences in the bacteriome profile

8 citations , March 2023 in “BMC Research Notes”

This pilot study explored a new method using laser-capture microdissection and 16S rRNA gene sequencing to analyze the human scalp hair follicle microbiome more accurately, revealing region-specific variations in microbial diversity and abundance.

research Laser Capture Microdissection Reveals Transcriptional Abnormalities in Alopecia Areata before, during, and after Active Hair Loss

16 citations , December 2015 in “Journal of Investigative Dermatology”

This study found significant gene expression abnormalities in hair follicles affected by alopecia areata, suggesting persistent changes that may predispose to future relapses even after hair regrowth.

research Folliculotropic mycosis fungoides with central nervous system involvement: Demonstration of tumor clonality in intrafollicular T cells using laser capture microdissection

14 citations , February 2003 in “Journal of the American Academy of Dermatology”

This case report describes the first use of laser capture microdissection to confirm that atypical lymphocytes in a folliculotropic mycosis fungoides case involving the central nervous system were part of the same tumor clone.

research 551 Combining Laser Capture Microdissection and RNAseq Analysis to Generate a Human Anagen Hair Follicle Transcriptome Atlas

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study generated a transcriptomic map of human hair follicles, identifying compartment-specific gene expression profiles that can aid in developing targeted therapies for hair follicle disorders.

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Community Join

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community Laser Diode Cap, I already use Oral Fin, Topical Min 5%, Nizoral and Microneedling

in Treatment 1 upvotes 10 months ago

The user is seeking advice on maximizing hair growth while using oral finasteride, topical minoxidil, Nizoral, and microneedling, and is considering adding a laser diode cap, topical finasteride, retinol, and caffeine. Suggestions include using tretinoin with minoxidil for better absorption, switching to dutasteride, and considering RU58841 or pyrilutamide.

community Recent Study finds Laser caps are more effective than 5% minoxidil for AGA

in Research/Science 124 upvotes 2 years ago

Laser caps are found to be more effective than 5% minoxidil for treating hair loss, and when combined with minoxidil, they are even more effective. Some users report positive results with laser treatments, while others see no change; the devices are FDA approved, but opinions on their efficacy vary.

community PRP / laser / stem cell treatment before or after hair transplant – worth it?

1 upvotes 4 weeks ago

The user is considering whether to undergo additional treatments like PRP, low-level laser therapy, and stem cell treatment before or after a planned hair transplant, while already using minoxidil and starting finasteride. They are unsure if these treatments are worth the significant cost and are seeking advice from others who have had similar experiences.

community kiierr laser cap.. does it actually work or just marketing hype?

in Chat 23 upvotes 1 month ago

Finasteride and minoxidil treatments plateaued after 10 months, leading users to explore additional options like microneedling and low-level laser therapy (LLT) caps, though many are skeptical of the effectiveness and marketing of LLT devices like Kiierr. Users express frustration with the lack of clear recommendations from dermatologists and the prevalence of marketing hype over genuine reviews.

community Korean Laser Helmet has a 44% increase in hair growth vs 0% growth in placebo in a double-blinded randomized controlled clinical trial.

3037 upvotes 11 months ago

A Korean laser helmet increases hair growth by 44% compared to a placebo. Users discuss its cost-effectiveness, clinical support, and compare it to treatments like finasteride and minoxidil, focusing on wavelength and energy density.

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Learn

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learn Low Level Laser Therapy

laser therapy for anti-inflammatory and likely insignificant hair regrowth effects

Is laser therapy safe to use at home, or should it always be done in a clinic? Laser therapy can be safe to use at home if using FDA-approved devices.
How does low level laser therapy actually stimulate hair growth? Low-level laser therapy stimulates hair growth by enhancing cellular energy production in hair follicles.
How many sessions of laser therapy are usually needed before noticing thicker hair? Visible improvement in hair thickness typically appears after three to six months of treatment.
All 5 questions on Low Level Laser Therapy →

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