Folliculotropic Mycosis Fungoides With Central Nervous System Involvement: Demonstration Of Tumor Clonality In Intrafollicular T Cells Using Laser Capture Microdissection

The study described a rare case of folliculotropic mycosis fungoides (MF) with central nervous system involvement. This was the first instance where laser capture microdissection was used to demonstrate that the atypical lymphocytes within the hair-follicle epithelium were part of the same tumor clone present in other tissue compartments. The findings supported the use of the term folliculotropic mycosis fungoides and confirmed that central nervous system involvement could occur in advanced stages of MF. The successful use of laser capture microscopy for analyzing atypical lymphocytes from hair-follicle epithelium marked a significant advancement in molecular diagnostics.