118 citations
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June 1993 in “Journal of Biological Chemistry” This study found that mouse and human protransglutaminase 3 enzymes require calcium-regulated activation for their role in later stages of cell envelope formation in the epidermis and hair follicle.
April 1996 in “Journal of Dermatological Science” April 2020 in “International Journal of Cosmetic Science” This study found that improved protein extraction methods enhanced the resolution of hair proteins on gels, but differences in protein abundance between curly and straight Japanese women’s hair were minimal and unlikely to affect hair structure.
4 citations
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November 2015 in “Research Journal of Medicinal Plant” This study found that ethanolic, aqueous, and hydroethanolic extracts of Tridax procumbens inhibited mitosis and caused mutagenic effects on cell division in Allium cepa root meristematic cells.
75 citations
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September 2015 in “Acta biomaterialia” This study found that alkylation of kerateine cysteine residues created a cell-compatible method for controlling hydrogel erosion rates and therapeutic agent release in keratin-based systems.
July 2007 in “Manuals in biomedical research” 13 citations
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March 2019 in “PLoS ONE” In this study, the authors developed a modified alkaline-based proteomics protocol that improved the reproducibility of detecting hair proteins, potentially aiding future biomarker discovery.
January 2014 in “Sen i Gakkaishi” In this study, liposome-encapsulated thioglycolic acid improved hair perming by enhancing the penetration of perm solutions, resulting in a stronger S-shaped wave and higher cysteine content compared to the control.
September 2023 in “Skin appendage disorders” This pilot study detailed the use of Hair-to-Hair-matching technology™ in a clinical trial to assess botulinum toxin's efficacy in treating male androgenetic alopecia, providing a precise method for evaluating hair count and thickness changes over time.
10 citations
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November 2018 in “Genetics in medicine” This study identified a genetic variant in the CTS6 gene associated with a hypotrichosis syndrome, emphasizing the significant role of cystatin M/E in hair and skin health.
103 citations
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February 1972 in “Proceedings of the National Academy of Sciences” This study found that a unique transglutaminase in guinea pig hair-follicles, distinct from liver transglutaminase, likely plays a role in forming protein cross-links via ε(γ-glutamyl)lysine bonds.
January 1995 in “Journal of the Society of Cosmetic Chemists” This study found no conclusive evidence of biocatalytic activity of guinea pig liver transglutaminase with virgin human hair, potentially due to a fatty acid layer on the hair surface.
July 2026 in “Biochemical and Biophysical Research Communications” 12 citations
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May 2023 in “Molecules” This study identified seven potential enzyme inhibitors from a Polygonum cuspidatum extract using ultrafiltration combined with high-performance liquid chromatography. These compounds showed inhibitory activity against tyrosinase, α-glucosidase, and xanthine oxidase, with most discovered in this extract for the first time.
7 citations
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March 2012 in “Journal of Investigative Dermatology” This study presents evidence that specific thymus-derived peptides affect human hair follicle growth, identifying thymulin as a potential hair growth stimulator despite interindividual response variations.
138 citations
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November 1977 in “Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics” 23 citations
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April 2003 in “Journal of Structural Biology” Keratin structure changes during keratinization, but the exact model remains uncertain.
October 2023 in “Jurnal Ilmu Kesehatan Hewan” This report describes the successful treatment of dermatophytosis due to Trychophyton spp. in a 2-month-old kitten using ketoconazole cream, fish oil, multivitamin syrup, and sulfur soap, resulting in significant improvement in the skin condition after four weeks.
49 citations
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January 1972 in “Biochimica et Biophysica Acta (BBA) - Protein Structure” 9 citations
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January 1981 This study found that the alkaline degradation process of hair keratin using nucleophilic reagents led to different proportions of reaction products compared to wool, particularly more lanthionine and lysinoalanine residues.
This study found that peptides from Lablab purpureus, particularly fraction 2, demonstrated potential anticancer effects by exhibiting significant antioxidant and apoptotic activities, selectively inhibiting cancer cells with minimal impact on healthy cells.
7 citations
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January 1997 in “Bioscience Biotechnology and Biochemistry” This study found that both types of sheep hair follicle transglutaminases were calcium-dependent, contradicting earlier reports of calcium independence in this enzyme.
30 citations
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August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that TGase 3 may contribute to hair fiber scaffolding by forming specific isopeptide bonds between keratin intermediate filaments and keratin-associated proteins.
28 citations
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June 2003 in “Applied immunohistochemistry & molecular morphology” This study demonstrated that combining cell conditioning with mild protease digestion enhanced the visualization of versican mRNA in formalin-fixed mouse skin tissue sections compared to using either technique alone.
28 citations
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June 1994 in “Journal of Dermatological Science” This study found that proteolytic activities in murine skin vary with hair cycle stages, with significant collagenase activity during the early anagen phase.
99 citations
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August 2009 in “Nature Genetics” This study found that combined loss of Atr and p53 in adult mice led to severe tissue degeneration and delayed regeneration due to the accumulation of highly damaged cells.
2 citations
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September 2016 in “Journal of Dermatological Science” Reduced TRPS1 leads to increased STAT3 and SOX9 in hair follicles, affecting hair growth.
9 citations
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January 2012 in “International journal of trichology” This case report suggests that Trichostasis spinulosa should be considered in diagnosing treatment-resistant open comedone-like lesions and that skin surface biopsy might be an effective diagnostic method.
December 2025 in “Journal of Food and Pharmaceutical Sciences” This study found that extracts and crude protein from the white oyster mushroom demonstrated significant thrombolytic activity compared to a positive control, suggesting their potential as natural thrombolytic agents for thromboembolism therapy.