Type II Keratins Are Phosphorylated on a Unique Motif During Stress and Mitosis in Tissues and Cultured Cells

June 2002 in “ Molecular Biology of the Cell ”

Diana M. Toivola, Qin Zhou, Luc S. English, M. Bishr Omary

type II keratins keratin phosphorylation LLS/TPL motif keratin solubilization filament reorganization proline-directed kinases p38 MAP kinase mitosis apoptosis psoriatic skin squamous cell carcinoma keratinocyte stress response mitogenic signaling skin-related diseases

Studysummary This study found that type II keratins in proliferating epithelial tissues are phosphorylated at a conserved motif during mitosis and stress, impacting keratin solubilization and reorganization.

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research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

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This study identified a new type II cytokeratin, named K6hf, exclusively expressed in the companion layer of the human hair follicle, distinguishing it from other keratins and suggesting a unique biochemical role.

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research Hair Follicle Differentiation: Expression, Structure, and Evolutionary Conservation of the Hair Type II Keratin Intermediate Filament Gene Family

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