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Glossary Trichoblastoma

rare benign tumor from hair follicle cells

Trichoblastoma is a rare, benign skin tumor that originates from the hair follicle cells. It typically appears as a small, slow-growing nodule on the scalp or face and is composed of cells that resemble the primitive hair matrix, making it important for dermatologists to distinguish it from more aggressive skin cancers.

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research Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma

87 citations , January 1999 in “British Journal of Dermatology”

This study found that trichoblastic fibroma and basal cell carcinoma cannot be differentiated by cytokeratin expression patterns, while trichoepithelioma lacks CK7 expression, distinguishing it from the other two neoplasms.

research Trichoblastic Carcinoma (“Malignant Trichoblastoma”) with Lymphatic and Hematogenous Metastases

80 citations , June 2000 in “Modern Pathology”

Long-standing benign tumors can become cancerous, especially in people with weakened immune systems.

research Merkel cell differentiation in trichoblastoma

34 citations , January 1998 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin”

This report describes four trichoblastoma cases rich in Merkel cells, suggesting these tumors may mimic fetal skin development where Merkel cells are numerous.

research Trichoblastoma with sebaceous and sweat gland differentiation

12 citations , May 2001 in “British journal of dermatology/British journal of dermatology, Supplement”

A rare benign skin tumor showed unusual features of sebaceous and sweat glands, important for correct diagnosis.

research Histopathological and Immunohistochemical Study of Trichoblastoma in the Rabbit

9 citations , August 2017 in “Journal of comparative pathology”

This study suggests that uncontrolled embryonic trichogenesis may play a role in the development of trichoblastoma in rabbits.

research Trichoblastoma of the Breast Detected by Screening Mammography: A Diagnostic Pitfall

6 citations , April 2010 in “The American Journal of Surgical Pathology”

This report highlights two cases where trichoblastoma in the breast was initially misdiagnosed as malignancy due to diagnostic challenges in needle core biopsies, emphasizing the importance of expert dermatopathologic review.

Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations

research Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg–like Cells, and Common EGFR Somatic Mutations

4 citations , May 2021 in “The American Journal of Surgical Pathology”

This study suggests that cutaneous lymphadenoma is a distinct benign lymphoepithelial tumor characterized by androgen receptor expression, hair follicle stem cell markers, and common EGFR gene mutations.

research Melanotrichoblastoma: A Histopathological Case Report of a Rare Pigmented Variant of Trichoblastoma

2 citations , August 2025 in “Reports — Medical Cases Images and Videos”

In this case report, a rare melanotrichoblastoma tumor was identified in a 51-year-old female following the histological and immunohistochemical analysis of a lesion on the pubo-inguinal area, presenting with strong epithelial marker positivity and a low proliferative index.

research Trichoblastic Carcinoma

2 citations , July 2001 in “Dermatologic Surgery”

This study reports two cases of trichoblastic neoplasms with histologic features suggesting they may be distinct, locally aggressive trichoblastic carcinomas separate from basal cell carcinoma.

research Eyebrow alopecia: centrofacial trichoblastomatosis

1 citations , March 2013 in “British Journal of Dermatology”

This correspondence discusses eyebrow alopecia in the context of centrofacial trichoblastomatosis and reports no new clinical findings.

research Clinicopathologic and molecular characterization of a series of sporadic trichoblastic neoplasms

November 2025 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin”

This study examined 16 sporadic trichoblastic tumors and found that although one showed malignant transformation, clinical follow-up revealed no residual or metastatic disease. RNA sequencing indicated a high tumor mutational burden and absence of a UV-related signature, helping to distinguish these tumors from similar growths.

research Trichoblastomas derived from the facial skin with tactile hair in aged house musk shrews (Suncus murinus)

December 2022 in “Laboratory Animal Research”

This study described two cases of trichoblastomas in the tactile hair skin of aged house musk shrews, highlighting that their histological structure differs from that in humans and other animals.

research A Case of Trichoblastoma

January 2003 in “Linchuang pifuke zazhi”

This case report describes a trichoblastoma in a 58-year-old man's leg, which was successfully excised without recurrence observed after 9 months.

research A Rare Case of Lower Back Swelling Diagnosed as Low- Grade Trichoblastic Carcinoma Following Excision: A Case Report

February 2025 in “American Journal of Medical Case Reports”

The case report highlights the diagnostic challenges of low-grade trichoblastic carcinoma, a rare malignant tumor often mistaken for benign lesions, in a 51-year-old female with immunocompromising conditions. Accurate diagnosis relied on histopathological examination, and achieving clear surgical margins was crucial to prevent recurrence.

research Arabinogalactan proteins are involved in root hair development in barley

32 citations , December 2014 in “Journal of experimental botany”

In this study, the authors concluded that arabinogalactan proteins recognized by specific antibodies are involved in the differentiation and development of barley root epidermal cells, contributing to root hair development.

research NAC1 directs CEP1-CEP3 peptidase expression and modulates root hair growth in Arabidopsis

1 citations , March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that AtCEPs in Arabidopsis thaliana play a role in controlling root hair growth by processing EXT proteins, with NAC1 acting to regulate their expression and influence elongation.

research Cytokeratins as Markers of Follicular Differentiation

121 citations , December 2001 in “American Journal of Dermatopathology”

This study found that trichoblastomas and nodular basal cell carcinomas have similar cytokeratin expression patterns, indicating differentiation towards the outer root sheath epithelium.

research Rippled‐pattern trichomatricoma

29 citations , February 1989 in “Journal of Cutaneous Pathology”

This case report identifies a new type of hair matrix tumor called "rippled pattern trichomatricoma," distinguished by its unique cell arrangement and differentiation features.

research The contribution of stem cells to epidermal and hair follicle tumours in the dog

18 citations , January 2013 in “Veterinary Dermatology”

This study found that K15 is a useful marker for investigating the role of stem cells in canine hair follicle tumours, while nestin is not optimal.

research Immunohistochemical Study of Calretinin in Normal Hair Follicles and Tumors With Follicular Differentiation

15 citations , January 2008 in “Actas Dermo-Sifiliográficas”

This study found that immunohistochemistry for calretinin may identify certain cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath.

research Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma

10 citations , December 2015 in “International Journal of Dermatology”

This study suggests that basal cell carcinoma and trichoblastoma may share differentiation toward the hair follicle, as indicated by strong positivity in CK 15, follistatin, and Bmi‐1 markers.

research Sox9 expression in canine epithelial skin tumors

8 citations , July 2015 in “European journal of histochemistry”

This study found that Sox9 was variably expressed in most canine skin neoplasms, particularly in those originating from the hair follicle's bulge region, suggesting its potential as a stem cell marker.

research Panfolliculoma: report of two cases

6 citations , June 2010 in “Dermatologica Sinica”

In this study, researchers reported two cases of the rare and benign follicular tumor called panfolliculoma, highlighting its differentiation across all hair follicle components, which is distinct from similar conditions like trichofolliculoma.

research Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation

4 citations , January 2019 in “Journal of cutaneous pathology”

This study found that phospho-S6 is strongly expressed in malignant hair follicle tumors but only patchily in a minority of benign tumors, indicating a potential marker for distinguishing between the two.

research A Pedunculated Follicular Hamartoma: A Case Showing a Central Trichofolliculoma‐like Tumor with Multiple Trichogenic Tumors

4 citations , August 1991 in “The Journal of Dermatology”

This case report describes a rare pedunculated follicular hamartoma on the nasal septum of a 77-year-old Japanese male, emphasizing its unique clinical and pathological features.

research Pathologic Quiz Case: A Cutaneous Nodule on the Left Temple

3 citations , December 2003 in “Archives of Pathology & Laboratory Medicine”

This article reviews the distinctive features of cutaneous lymphadenoma, a variant of trichoblastoma, and its differential diagnosis, but it presents no new empirical results.

research Hair follicle tumors in dogs: A report of two cases

1 citations , January 2015 in “Indian Journal of Veterinary Pathology”

This report describes cases of trichoblastoma and trichoepithelioma in mixed-breed dogs, highlighting their distinct microscopic characteristics without suggesting broader clinical implications.

Histopathological Characteristics May Not Be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appendages Originating from Hair Follicle

research Histopathological Characteristics may not be Useful in the Differential Diagnosis Between Basal Cell Carcinoma and Benign Tumors of Cutaneous Appandages Originating from Hair Follicle

1 citations , September 2011 in “UHOD : Uluslararası hematoloji - onkoloji dergisi”

This study found no significant differences in age, sex, or histopathological characteristics for differentiating basal cell carcinoma from benign tumors of cutaneous appendages, complicating diagnosis.

research A Case of Hair Transplantation in a Nevus Sebaceus Followed by Secondary Tumors, Maintaining the Hair Cycle for Approximately 40 years

March 2026 in “The Journal of Dermatology”

This case study describes a 70-year-old woman with a congenital skin condition, nevus sebaceus, who underwent hair transplantation which maintained hair growth for about 40 years; however, secondary tumors developed over time, highlighting the persistence of tumorigenic potential within nevus sebaceus.

research Secondary Neoplasm Arising in Nevus Sebaceus of Jadassohn: A Case Report Emphasizing Early Recognition and Evaluation

March 2026 in “Scientific Journal”

This case study reported a 15-year-old girl with a nevus sebaceus of Jadassohn, where a secondary neoplasm potentially developed into either pigmented trichoblastoma or pigmented basal cell carcinoma, highlighting the importance of early recognition and evaluation of such lesions for effective management.