Pathologic Quiz Case: A Cutaneous Nodule on the Left Temple

    December 2003 in “ Archives of Pathology & Laboratory Medicine ”
    Vilkesh R. Jaiswal, Robin H. Amirkhan, Mai P. Hoang
    TLDR The nodule was a benign cutaneous lymphadenoma, not cancer, and was successfully removed.
    A 65-year-old man presented with a cutaneous nodule on his left temple, initially suspected to be basal cell carcinoma, but was diagnosed as cutaneous lymphadenoma after excision. This rare benign tumor, considered a variant of trichoblastoma, is characterized by epithelial nests with peripheral palisading and a lymphocytic infiltrate. Immunohistochemical analysis showed strong labeling of basaloid cells and epithelial cells with clear cytoplasm, while CD3 highlighted T lymphocytes. The tumor is distinct from basal cell carcinoma and other similar conditions due to its unique histological features and lymphoid response. The patient remained disease-free over 2 years post-surgery.
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