123 citations
,
February 2002 in “Journal of The American Academy of Dermatology” Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.
122 citations
,
December 2022 in “International Journal of Molecular Sciences” In this review, researchers discussed recent advances in nanotechnology for topical skin applications, highlighting how nanocarriers enhance skin penetration and targeting in treatments for diseases like melanoma and psoriasis, while acknowledging that the penetration mechanisms and health impacts of nanoparticles remain not fully understood.
115 citations
,
January 2001 in “American journal of clinical dermatology” This study found that eflornithine 15% cream reduced unwanted facial hair growth more effectively than a placebo in women with hirsutism, but hair growth returned to pretreatment levels within 8 weeks of stopping treatment.
104 citations
,
March 1987 in “Journal of The American Academy of Dermatology” Minoxidil helps hair growth in 63.6% of alopecia patients, with 27.3% having excellent results.
101 citations
,
November 1992 in “Archives of Dermatology” In this study, tapering prednisone followed by 2% topical minoxidil helped limit hair loss in some patients with alopecia areata, with 30% to 47% showing over 25% hair regrowth initially.
101 citations
,
March 1987 in “Journal of The American Academy of Dermatology” Minoxidil solution helps hair regrowth in alopecia areata, with 5% being more effective.
99 citations
,
June 2005 in “Endocrinology” This study found that applying supraphysiologic doses of topical T3 significantly accelerated wound healing in mice compared to a control vehicle, suggesting its potential as a cost-effective wound treatment.
96 citations
,
December 2015 in “JAMA dermatology” This article discusses the potential of topical ruxolitinib as a treatment for alopecia universalis and acknowledges the need for alternatives to systemic JAK inhibitors due to the risk of serious side effects.
95 citations
,
June 2002 in “The Journal of Dermatology” In this study, using topical crude onion juice significantly improved hair regrowth in patients with patchy alopecia areata compared to tap water.
91 citations
,
April 2011 in “Journal of Ethnopharmacology” This study found that Polygonum multiflorum extract may promote hair growth by inducing the anagen phase in the resting hair follicles of mice.
83 citations
,
June 2017 in “Journal of the American Academy of Dermatology” This study observed that most pediatric patients with alopecia areata experienced some hair regrowth after treatment with topical JAK inhibitors, and the formulations were generally well-tolerated with mild lab abnormalities in some cases.
80 citations
,
September 1984 in “Journal of The American Academy of Dermatology” In this study, 5% topical minoxidil was observed to promote hair regrowth in some patients with androgenic alopecia, while no regrowth was noted in patients with alopecia areata.
80 citations
,
October 1983 in “BMJ” This study found that 1% topical minoxidil induced significant hair regrowth in patients with alopecia areata, though it was less effective for those with extensive hair loss such as alopecia totalis and universalis.
78 citations
,
April 1984 in “Archives of Dermatology” This study found that 1% minoxidil topical solution led to terminal hair regrowth in some patients with alopecia areata, though it was only cosmetically acceptable in less than half of those cases.
76 citations
,
January 2004 in “Journal of Investigative Dermatology” 73 citations
,
October 1986 in “Journal of the American Academy of Dermatology” This study found that a combination of topical tretinoin and 0.5% minoxidil resulted in terminal hair regrowth in 66% of subjects with androgenetic alopecia over one year.
72 citations
,
December 2012 in “Expert Opinion on Drug Delivery” This review discusses niosomes' increasing popularity in dermatology for topical drug delivery due to their ability to enhance drug penetration, provide sustained release, and carry various drugs, while reporting no new clinical findings.
70 citations
,
April 1990 in “Journal of The American Academy of Dermatology” Minoxidil treatment increased hair growth for up to 5 years, requiring twice daily application.
69 citations
,
March 2016 in “American journal of clinical dermatology” Topical retinoids effectively improve photodamaged skin.
69 citations
,
February 1987 in “Archives of Dermatology” This case report describes the topical application of cyclosporine in a man with alopecia universalis, which showed hair regrowth after 10 months of daily use, except where limited by a congenital nevus.
67 citations
,
March 1987 in “Journal of The American Academy of Dermatology” This study found that both 2% and 3% minoxidil resulted in a significant increase in hair counts for participants with androgenetic alopecia over 12 months.
63 citations
,
April 2018 in “Journal of the American Academy of Dermatology” This review discusses the efficacy and safety of topical JAK inhibitors for inflammatory skin conditions, reporting modest benefits in psoriasis and atopic dermatitis but mixed results for vitiligo and inconclusive data for alopecia areata.
63 citations
,
April 1985 in “Journal of the American Academy of Dermatology” This study observed that topical PUVA treatment led to excellent or good hair regrowth in 45.4% of patients with alopecia areata, though many experienced relapse after treatment stopped.
61 citations
,
May 2016 in “Scientific reports” This study found that IMT-P8, a novel cell-penetrating peptide, effectively facilitated the dermal delivery of proteins and peptides in mouse skin and cell lines, suggesting potential for topical applications in cosmetics and skin diseases.
61 citations
,
April 2014 in “Radiation Research” This study observed that topically applied RTA 408 reduced the severity of radiation-induced dermatitis in mice, with the highest dose significantly reducing and alleviating skin damage and associated inflammation.
61 citations
,
January 2007 in “Indian Journal of Dermatology Venereology and Leprology” This study found that garlic gel significantly improved the efficacy of topical betamethasone valerate in treating alopecia areata compared to placebo.
60 citations
,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.
60 citations
,
September 2001 in “British journal of dermatology/British journal of dermatology, Supplement” This review discusses the use of contact sensitizers in topical immunotherapy for conditions like alopecia areata and viral warts, focusing on treatment methods, efficacy, and potential adverse effects, and reports no new clinical results.
60 citations
,
February 1997 in “Journal of Dermatological Science” This study demonstrated that phosphatidylcholine liposomes can deliver calcein and melanin into hair follicles and shafts in mice without significant penetration into the dermis, epidermis, or bloodstream.
58 citations
,
December 2012 in “Aaps Pharmscitech” This study suggests that finasteride-loaded liquid crystalline nanoparticles could be a viable alternative to oral administration for treating androgenetic alopecia due to their controlled release and skin permeation properties.