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This review describes bioengineering strategies to mimic the natural cell microenvironment in vitro, emphasizing the novel approach of using cell-synthesized extracellular matrix as a scaffold for engineering functional 3D tissues, while highlighting the limitations of exogenous scaffolds in tissue engineering.

This study found that human adipose-derived stem cells co-cultured on a collagen sponge scaffold showed increased differentiation into keratinocytes, suggesting potential for improved skin wound healing.

This study found that mesenchymal progenitor cells from human hair roots seeded onto polymer scaffolds stimulated the production of mineralized proteins, enhancing bone-like structures, with optimal results at a pore size of 35 µm.

This review discusses the principles, materials, and applications of melt electrowriting-based 4D printing for creating biomimetic scaffolds, but reports no new clinical results; it highlights recent advancements and remaining challenges in the field.

This study reported that nanofibrous scaffolds made from a PVA and flaxseed extract combination showed enhanced antimicrobial activity and significantly better wound healing in vitro compared to pure PVA fibers.

In this study, adipose-derived stem cells from human scalp were successfully directed towards chondrocyte differentiation, with TGF-beta3 and BMP-6 growth factors proving effective for in vitro chondrogenesis.

This study developed granular hydrogels with reversible interparticle cross-linking, finding they offer high mechanical stability and enhance cell recruitment, making them promising for injectable and 3D printable scaffolds in tissue engineering and therapeutic delivery.

This study found that RADA-PRG hydrogels enhanced skin-derived precursor cell proliferation and improved hair follicle neogenesis in mice, suggesting potential use as a scaffold material in tissue engineering.

This review highlights that incorporating nanomaterials into scaffolds can significantly enhance angiogenesis in tissue regeneration by simulating extracellular matrix structures and effectively delivering angiogenesis-related factors, offering promising designs for vascularization and therapeutic applications.

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

This study systematically examines how smart biomaterials used with DLP technology can enhance bioprinting in tissue engineering and regenerative medicine, while also identifying current challenges and future research needs.

This review discusses recent advancements and ongoing challenges in engineering human skin with appendages using scaffold-free and scaffold-based bioengineering approaches, but it reports no new clinical results.

This review highlights recent advancements in microfluidics for 3D tissue model generation and discusses its applications in tissue engineering and high-throughput drug screening without reporting new experimental results.

In this study, chitosan-modified fucoidan/polyethylene oxide nanofibers were developed, showing promise as bio-scaffolds for tissue-engineered blood vessels by enhancing endothelial cell adhesion and inhibiting monocyte attachment.

This review discusses current wound management strategies and examines electrospun nanofibers with biological macromolecules for their potential in tissue engineering and drug delivery, but reports no new clinical results.

This review introduces a framework to integrate bioinspired conductive materials and advanced 3D/4D printing in regenerative medicine for dynamic, responsive tissue regeneration, emphasizing the potential of smart scaffolds to adapt to physiological cues.

This review discusses the use of platelet-rich plasma in regenerative dentistry, highlighting its biological principles, clinical applications, and the challenges encountered in PRP-based strategies for oral tissue engineering, but reports no new results.

This review highlights the use of droplet microfluidics in microgel fabrication, emphasizing its ability to control microgel properties and discussing applications in areas like drug delivery and tissue engineering, as well as addressing current challenges and future research directions.

This study reported that a novel bilayer wound dressing made from PLCL nanofibers and keratin hydrogel, loaded with FGF-2, promoted skin healing and showed potential for use in skin tissue engineering.

This study found that a bioactive borosilicate glass containing Sr and Cu ions exhibited promising mechanical strength, biocompatibility, and antibacterial activity, particularly the CuSr-1 wt.% composition, suggesting potential for use in orthopedic implants and bone tissue engineering.

This study investigated nanocomposite scaffolds made from alginate, chitosan, and graphene oxide to promote the proliferation of spermatogonial stem cells, finding the ALGCS/GO30 scaffold to be particularly effective due to increased proliferation markers and PLZF protein expression compared to controls.

This article reviews the use of mesenchymal stem cells and biomimetic scaffolds in regenerative medicine, highlighting promising in vitro and in vivo outcomes, but it reports no new clinical results.

This review discusses the potential of mesenchymal stem cells from the oral cavity for tissue regeneration in oral and maxillofacial surgery but reports no new clinical results.

This study found that incorporating PCL-based nanoscaffolds into liver spheroids enhances their viability and liver-specific biofunctionality, suggesting these scaffolds improve the model's potential for preclinical drug screening by increasing sensitivity to acetaminophen toxicity compared to traditional methods.

This study introduces a magnet-assisted fabrication strategy for creating complex 3D soft bioscaffolds, demonstrating its effectiveness by producing structures with overhangs and supporting biohybrid actuators, promising advancements in biomedical applications.

This study provides a comprehensive review of the use of electrospinning technology to create 3D porous structures for bone implants, emphasizing the synergy between biomedicine and materials science necessary for developing orthopedic materials.

This review discusses the medical and dental applications of polyhydroxyalkanoates (PHAs), highlighting their potential for improving drug delivery and providing biocompatible solutions for medical devices, but reports no new clinical results.

This study found that strontium ranelate promotes cartilage regeneration in rats by enhancing chondrogenic differentiation of bone mesenchymal stem cells while inhibiting the Wnt/β-catenin signaling pathway.

This review highlights advancements in electrospun nanofibers, focusing on their potential applications in biomedical technologies, chemical and biological sensing, and energy harvesting within IoT devices.

This review discusses how polymers can be customized to develop biomaterials that mimic the extracellular matrix, exploring their potential in biomedical and biotechnological applications by triggering cell functions similar to natural physiological systems.