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In this study, treatments combining betamethasone and anovulatory steroids significantly reduced testosterone production in women with hirsutism, with many reporting improved hirsutism and acne, although clinical benefit did not consistently correlate with testosterone reduction.

In this case report, a 68-year-old woman with a Leydig cell tumor of the ovary experienced virilization, and surgical removal led to normalization of testosterone levels and regression of symptoms.

This study found that in male mouse pancreatic islet β cells, testosterone enhances glucose-stimulated insulin secretion by being locally converted into dihydrotestosterone and estradiol.

This study suggests that gender-affirming testosterone therapy in transgender men is generally safe and effective with adequate screening and monitoring, although high-quality long-term studies are lacking.

This study suggests that 5-ADIOL-S may contribute to the synthesis of potent androgens in peripheral tissues, and 3 alpha-DIOL-S could be a marker of androgen metabolism in various female patient groups.

This case report discusses a postmenopausal woman whose hyperandrogenism and metabolic symptoms improved significantly after the surgical removal of an ovarian Leydig cell tumor, confirmed post-operatively.

This review examines the pharmacological evidence and bioactive compounds in Hibiscus plants, supporting their potential importance for developing treatments for chronic and degenerative diseases, though more research is needed.

This study found that transgender men using testosterone therapy had higher rates of acne and increased body hair growth, resembling male patterns more closely than those not on testosterone.

High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.

Androgens affect behavior, hair, bones, muscles, and the heart, and can be used to treat certain conditions.

The woman likely has a hormonal imbalance causing excessive hair growth.

This case report describes a postmenopausal woman with hirsutism and androgenetic alopecia, where imaging ruled out malignancy and selective venous sampling indicated increased testosterone from the right adrenal vein, leading to a recommendation for right adrenalectomy and oophorectomy.

This study found that a self-assessed modified Ferriman-Gallwey score of 10 or higher indicates excess body hair, and suggests androstenedione measurement should accompany testosterone when evaluating hyperandrogenism.

This case study describes two postmenopausal women with severe androgen excess symptoms, diagnosed with ovarian hyperthecosis and stromal hyperplasia, emphasizing the challenges in differentiating these benign conditions from androgen-secreting tumors and the importance of surgical and histopathological evaluation for correct diagnosis and management.

This study found that in patients with severe aortic valve stenosis, higher serum dihydrotestosterone levels were associated with increased myocardial hypertrophy, fibrosis, and reduced left ventricular function.

In this review and meta-analysis, the authors concluded that 5α-reductase inhibitor therapy is not consistently associated with significant increases in serum testosterone levels in men.

This study found that administering a supraphysiological dose of testosterone to female rats significantly reduced estrogen and progesterone levels, disrupted sex steroid receptor expression, and interfered with the embryonic implantation window, indicating potential implications for androgen-related endometrial conditions.

In this study, the authors observed that testosterone therapy shortened the QTc interval and normalized T-wave morphology in men with acquired LQTS or TdP linked to hypogonadism, suggesting testosterone may be helpful in treatment.

Doctors used a special blood sampling technique to diagnose a woman's rare ovarian tumor that was producing male hormones.

A 73-year-old woman's unusual hair loss and growth led to the discovery of a rare condition causing too much testosterone, which improved after her ovaries were removed.

In this study, long-term normalization of testosterone levels in postmenopausal women with hyperandrogenism did not improve body mass index, glucose, or lipid metabolism.

This study found that among older men, lower calculated free testosterone was significantly associated with a higher risk of heart failure, suggesting a possible role of testosterone deficiency in heart failure incidence.

This case study describes a testosterone-secreting adrenal adenoma in a 55-year-old woman, highlighting the presence of Reinke's crystalloids, suggesting that Leydig cells may play a role in such tumors.

This case report describes two transgender men using subdermal testosterone pellets for gender affirmation, finding they tolerated the treatment, but one returned to injections; firm conclusions on pellets' suitability require further study.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

This article discusses the role of testosterone in the formation of male characteristics, muscle and bone development, and its impact on skin and hair, but provides no new clinical results.

This article reviews the role of testosterone in sexual health, supporting Testosterone Replacement Therapy as an effective treatment for Hypoactive Sexual Desire Disorder in postmenopausal women, though more research is needed on its long-term effects and applicability to premenopausal women.

This case report highlights that uncommon ovarian tumors like sclerosal stromal tumors can cause hirsutism and virilization in postmenopausal women and lead to androgen secretion, despite typically being hormonally inactive.

This animal study observed that dihydrotestosterone increased arterial stiffness and decreased estrogen receptor expression in female mice, potentially impacting cardiovascular health in contexts of androgen use.