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Finasteride, when taken daily, lowers dihydrotestosterone levels but doesn't noticeably affect adrenal steroid production, except by blocking the 5 alpha-reductase enzyme.

Serenoa repens is mostly safe but has some risks, especially at high doses or when used with other products for over two weeks.

Lacking cyclin D3 reduces skin cancer growth without affecting normal skin cell growth.

Obesity leads to physical, metabolic, reproductive issues, higher healthcare costs, and mental health problems.

Men with androgenetic alopecia and hypertension may experience more severe COVID-19.

A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.

A pineal tumor caused a boy's early puberty, which changed from peripheral to central after treatment.

Too much male hormone in mothers can negatively affect the sexual behavior of both male and female baby mice.

Testosterone replacement therapy helps manage deficiency and has various methods, but requires careful monitoring to avoid side effects.

Teak leaf extract contains compounds that could help treat hair loss.

A man with both Klinefelter syndrome and primary hyperparathyroidism showed a rare combination of symptoms and genetic patterns.

Bioengineered nanoparticles can effectively treat hair loss by targeting specific enzymes and receptors.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Progeroid mouse models show signs of early aging similar to humans, helping us understand aging better.

Early diagnosis and a strict gluten-free diet are crucial for children with celiac disease to improve symptoms.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

Oral estradiol works for many transgender women but needs personalized dosing and monitoring.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Testosterone may influence COVID-19 severity and outcomes.

The review suggests new ways to classify ejaculation problems and recommends different treatments based on the type of issue.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Combination therapies for androgenetic alopecia work best but can have significant side effects and costs.

Managing oxidative stress might help treat low testosterone and related chronic diseases in aging men.

Metformin works better for adolescent girls with PCOS who have certain genetic variations.

Acyzol could help treat conditions caused by zinc deficiency.

Baicalin may help reduce excessive male hormone levels in PCOS.

Treating hair loss in both men and women is effective and improves quality of life.