Central Precocious Puberty Secondary to Peripheral Precocious Puberty Due to a Pineal Germ Cell Tumor: A Case and Review of Literature

October 2023 in “ BMC endocrine disorders ”

Han Chen, Caiyan Mo, Liyong Zhong

central precocious puberty peripheral precocious puberty pineal germ cell tumor human chorionic gonadotropin HCG gonadotropins testosterone gonadotrophin-releasing hormone analog therapy melatonin central PP peripheral PP pineal tumor GnRH analog therapy

TLDR A pineal tumor caused a boy's early puberty, which changed from peripheral to central after treatment.

The document discusses a case of a 5.8-year-old male who developed central precocious puberty (PP) due to a pineal germ cell tumor. The tumor was secreting human chorionic gonadotropin (HCG), causing peripheral PP. After chemoradiotherapy and surgery, the HCG levels normalized, but the levels of gonadotropins and testosterone increased, indicating a transition to central PP. This was managed with gonadotrophin-releasing hormone analog therapy. The document concludes that clinicians should be aware of the potential for secondary central PP in patients with pineal HCG-secreting tumors. An increase in gonadotropin levels prior to a decrease in sex steroids may indicate a transition to central PP related to melatonin.

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Central Precocious Puberty Secondary to Peripheral Precocious Puberty Due to a Pineal Germ Cell Tumor: A Case and Review of Literature

Research cited in this study

research Isosexual Precocious Pseudopuberty Secondary to a Testosterone-Secreting Leydig Cell Testicular Tumor: True Isosexual Development Early After Surgery

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