October 2023 in “BMC endocrine disorders” In this case study, researchers observed a 5.8-year-old male with peripheral precocious puberty due to a germ cell tumor, marked by elevated human chorionic gonadotropin levels. Treatment normalized hormone levels and arrested the puberty progression, highlighting melatonin's potential role in transitions to central precocious puberty.
April 2025 in “International Journal For Multidisciplinary Research” This case report details the investigation and management of a 3-year-old girl with precocious pseudopuberty due to a Sertoli-Leydig cell tumor, highlighting the importance of early recognition and accurate diagnosis for effective treatment and prognosis.
January 2015 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” In this case report, tamoxifen-induced hirsutism was observed in a young girl with McCune-Albright syndrome shortly after starting treatment.
October 2022 in “Medical Clinical Update Journal” This case report describes a 7.5-year-old girl with precocious puberty displaying significant secondary sexual development and advanced bone age, treated monthly with Leuprolide.
January 2024 in “Frontiers in endocrinology” This study found that women treated with GnRHa for central precocious puberty had a higher prevalence of polycystic ovary syndrome in adulthood compared to those with isolated premature thelarche.