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The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Massage increases how deep both rigid and flexible liposomes can go into skin, with flexible ones going deeper, and covering the skin (occlusion) helps rigid ones more.

Minoxidil-loaded liposomes effectively deliver to hair follicles, potentially improving hair growth and treating alopecia.

Liposomes improve the delivery and effectiveness of cosmetic ingredients but face challenges like cost and stability.

Sebaceous glands in our skin, developing during pregnancy and active in puberty, produce sebum for skin lubrication, temperature control, and fighting germs, also help in hormone regulation, and their dysfunction can cause conditions like acne and hair loss.

Acne and increased body hair in teenage girls are normal but severe cases may need hormone evaluation and treatment can prevent diabetes linked to PCO.

Ethanol pretreatment affects drug penetration through skin and hair follicles.

Older age and certain lifestyles are linked to thinner, weaker hair, while how you see your hair relates to its thickness.

Azelaic acid may help treat acne by killing bacteria, reducing inflammation, and preventing clogged pores.

A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.

Men are increasingly seeking quick-result cosmetic treatments for their thicker, oilier skin and hair loss issues.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Liposomes could improve how skin care products work but are costly and not very stable.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

PEVs effectively deliver minoxidil through skin.

The gel with special fat-loaded particles from rice bran could be an effective skin treatment for hair loss.

Environmental and cosmetic factors, including heat, chemicals, and sun exposure, can cause hair loss and damage.

Using sonophoresis can make it harder for certain drug-loaded liposomes to get through the skin.

The document concludes that hair follicles have a complex environment and our understanding of it is growing, but there are limitations when applying animal study findings to humans.

Hair follicles could be used for targeted drug delivery, with liposomal systems showing promise for this method.

Hair follicles could be used to deliver drugs effectively, with the right understanding and methods.

Chitosan slows root hair growth and causes a buildup of callose at low concentrations, but at high concentrations, it only inhibits growth without callose buildup.

Mozuku seaweed fucoidan can inhibit harmful skin bacteria growth.

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.