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    Glossary Steroids

    Steroids are synthetic substances that mimic the effects of hormones like testosterone in the body. They are often used in medical treatments but can also lead to hair loss as a side effect, particularly when they disrupt the natural hormonal balance. In the context of hair biology, anabolic steroids can cause androgenic alopecia, a condition characterized by thinning hair and baldness, especially in genetically predisposed individuals. Key distinguishing characteristics include their potential to increase hair loss in both men and women, depending on individual sensitivity to androgens.

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    1. Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition Endocrine Reviews · 2005 · 451 citations
    2. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    3. Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1) Journal of Investigative Dermatology · 2003 · 289 citations
    4. LC‐MS/MS‐based method for long‐term steroid profiling in human scalp hair Clinical Endocrinology · 2015 · 134 citations
    5. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne Cochrane library · 2009 · 112 citations
    6. Steroid sulfatase inhibitors Medicinal Research Reviews · 2004 · 108 citations
    7. Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1992 · 101 citations
    8. A preliminary study of steroid reproductive hormones in human hair The Journal of Steroid Biochemistry and Molecular Biology · 1998 · 89 citations
    9. Role of Transepidermal and Transfollicular Routes in Percutaneous Absorption of Steroids: In vitro Studies on Human Skin Skin Pharmacology and Physiology · 1994 · 82 citations
    10. Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency The Journal of Clinical Endocrinology and Metabolism · 2008 · 81 citations
    11. Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones International Journal of Pharmaceutics · 2006 · 75 citations
    12. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011 · 72 citations
    13. Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review Oncotarget · 2018 · 65 citations
    14. The influence of selected steroid hormones on the physicochemical behaviour of DPPC liposomes Chemistry and Physics of Lipids · 2007 · 65 citations
    15. Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids Frontiers in endocrinology · 2018 · 61 citations
    16. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001 · 61 citations
    17. Local Injection of Steroids and Hair Regrowth in Alopecias Archives of Dermatology · 1960 · 57 citations
    18. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    19. GC-MS determination of steroids related to androgen biosynthesis in human hair with pentafluorophenyldimethylsilyl–trimethylsilyl derivatisation The Analyst · 1999 · 56 citations
    20. STEROIDS AND STEROID-LIKE COMPOUNDS Clinics in Sports Medicine · 1999 · 55 citations
    21. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    22. Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases The Journal of Steroid Biochemistry and Molecular Biology · 2013 · 51 citations
    23. A systematic review of pulse steroid therapy for alopecia areata Journal of the American Academy of Dermatology · 2016 · 50 citations
    24. Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues Molecular and Cellular Endocrinology · 2013 · 48 citations
    25. Skin steroidogenesis in health and disease Reviews in endocrine and metabolic disorders · 2016 · 47 citations
    26. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex Journal of Biological Chemistry · 2009 · 47 citations
    27. Steroid plant hormones: Effects outside plant kingdom Steroids · 2014 · 46 citations
    28. Sex steroid synthesis in human skin in situ: The roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin Molecular and Cellular Endocrinology · 2012 · 46 citations
    29. Steroid 17β-hydroxysteroid dehydrogenase deficiency in man: An inherited form of male pseudohermaphroditism The Journal of Steroid Biochemistry and Molecular Biology · 1992 · 46 citations
    30. Towards the validation of endogenous steroid testing in wildlife hair Journal of applied ecology · 2018 · 44 citations