TLDR New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.
The study investigated the antihormonal properties of new A-homo-B, 19-dinor steroids of the androstane series. Through solvolysis of Westphalen-type steroids with a leaving group in the position 6β, products of elimination, rearrangement, and fragmentation were prepared and converted to analogs of a compound known to promote hair growth. Compounds 11 to 13 demonstrated strong antiandrogenic activity in vivo, but this activity could not be explained by inhibition of 5α-reductase or strong binding to an androgen receptor.
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