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Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

PCOS management includes lifestyle changes and medications, with ongoing research into repurposed drugs for better treatment options.

Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

Melatonin, a hormone, can help protect skin from aging by reducing stress, inflammation, and damage, and may also help treat hair loss in women.

Pioglitazone improved insulin sensitivity and altered cortisol metabolism in PCOS patients.

Testosterone's effects on COVID-19 are unclear and need more research.

Hormones affect prostate health and disease, with certain hormone imbalances linked to prostate cancer and benign prostatic hyperplasia.

Certain brain hormones and chemicals are linked to the development of Polycystic Ovary Syndrome.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

14,15-EET may help reduce poststroke pain by affecting certain brain proteins.

The document concludes that a systematic approach is crucial to identify causes of androgen excess in women beyond the most common cause, Polycystic ovary syndrome (PCOS).

Men with hormonal imbalances similar to PCOS may have increased risk of metabolic and heart diseases.

Polycystic ovary syndrome increases the risk of diabetes, heart disease, and endometrial cancer, and requires early treatment to manage these risks.

Diagnosing and treating PCOS in teenagers is difficult, and the focus is on lifestyle changes and medication to improve health and prevent future issues.

Cinnamon can help manage symptoms of polycystic ovary syndrome, improve menstrual cycles and fertility, and positively affect cholesterol and blood sugar levels, but more research is needed to confirm these effects and find the best dosage.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Healthy lifestyle changes can significantly improve skin health as you age.

The testes produce important hormones like testosterone and others that play key roles in male body functions.

Eating a Mediterranean diet and taking certain supplements may improve symptoms of PCOS.

Some women with PCOS have rare genetic variants linked to the condition.

Origanum vulgare leaf extract reduces liver and kidney damage caused by finasteride in mice.

Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.

Hormonal imbalances can cause hair loss, and understanding them can help develop better treatments.

Women with PCOS are more likely to have skin problems like excessive hair, acne, and hair loss.

Higher androgen levels during puberty are linked to shorter adult height in boys with Silver-Russell syndrome.

Some common medications may harm male fertility by affecting hormones, sperm production, and sexual function.

Women with PCOS may have a higher risk of severe COVID-19 due to hormonal imbalances and vitamin D deficiency.