Endocrinology of the Aging Prostate: Current Concepts

    February 2021 in “ Frontiers in Endocrinology ”
    Rossella Cannarella, Rosita A. Condorelli, Federica Barbagallo, Sandro La Vignera, Aldo E. Calogero
    Image of study
    TLDR Hormones affect prostate health and disease, with certain hormone imbalances linked to prostate cancer and benign prostatic hyperplasia.
    The 2021 document "Endocrinology of the Aging Prostate: Current Concepts" discussed the role of hormones in prostate health and disease, particularly focusing on estrogen, insulin-like growth factor (IGF), and thyroid hormones. The document cited studies showing that estrogen receptor alpha drives proliferation in prostate carcinoma and that loss of ERbeta expression is a common step in estrogen-dependent tumor progression. IGF deficiency was linked to metabolic syndrome and IGF1 was related to prostate cancer and benign prostatic hyperplasia (BPH). Increased serum triiodothyronine (T3) levels were found in men with prostate cancer and BPH. The document also highlighted the link between metabolic syndrome and BPH, with hyperinsulinemia and dyslipidemia as risk factors. The research suggested that androgen-targeted therapies could induce changes in prostate cancer cells, contributing to the development of castration resistance. Obesity and hyperinsulinemia were identified as risk factors for prostate cancer. The potential use of metformin in improving the survival of diabetic prostate cancer patients was discussed. The document also suggested a possible genetic link between polycystic ovary syndrome (PCOS) and androgenetic alopecia, indicating that a male equivalent of PCOS might exist. Androgenetic alopecia was suggested as an early marker of BPH and prostate cancer, but more research is needed to confirm these associations.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 974 results

      community Dht kills hair, but no one says why?

      in Finasteride/Dutasteride  40 upvotes 1 month ago
      DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

      community Serum based on plant extracts boosts hair growth in weeks.

      in Treatment  39 upvotes 6 days ago
      A serum containing Centella asiatica extracellular vesicles, IGF-1, FGF-7, and caffeine significantly improved hair thickness, density, length, and reduced hair loss after 56 days. The conversation also discusses how treatments like finasteride, minoxidil, and ketoconazole address different aspects of hair loss by reducing DHT, improving blood flow, and lowering inflammation.

      community 2 years on treatment (stack update)

      in Progress Pictures  459 upvotes 7 months ago
      A user shared their hair regrowth progress using Dutasteride, topical Minoxidil, Spironolactone, and Estradiol Valerate injections as part of hormone replacement therapy for transitioning. They experienced significant hair improvement and personal satisfaction but caution against this approach for non-transitioning individuals due to irreversible changes.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 3 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Ultimate Stack without nuking your gender (you'll go broke)

      in Treatment  82 upvotes 10 months ago
      A hair loss treatment plan includes finasteride, dutasteride, RU58841, pyrilutamide, minoxidil, and microneedling to inhibit DHT and promote hair growth. It also recommends supplements like Reishi and Lion’s Mane mushrooms, and a shampoo with ketoconazole, caffeine, and melatonin.

    Related Research

    4 / 4 results