Adrenal and Gonadal Activity, Androgen Concentrations, and Adult Height Outcomes in Boys With Silver-Russell Syndrome

The study investigated adrenal and gonadal activity, androgen concentrations, and adult height outcomes in 13 boys with Silver-Russell Syndrome (SRS). It found that boys with SRS had altered adrenal and gonadal function, leading to higher androgen concentrations, which negatively impacted adult height. Non-responders (NRs) had higher levels of DHEAS, androstenedione, testosterone, and dihydrotestosterone (DHT) compared to responders (Rs), and lower anti-Müllerian hormone (AMH) levels at age 12. The study suggested that increased androgen secretion, particularly from the testes, contributed to elevated estradiol levels, impairing adult height outcomes. Monitoring and addressing these endocrine abnormalities were highlighted as important for improving growth outcomes in boys with SRS.