Premature Adrenarche, Polycystic Ovary Syndrome, and Intrauterine Growth Retardation: Does a Relationship Exist?

    February 2007 in “ Current Opinion in Endocrinology, Diabetes and Obesity ”
    Mirjam M. van Weissenbruch
    Studysummary This review discusses the early developmental origin of premature adrenarche and polycystic ovary syndrome and highlights potential utero-based mechanisms, reporting no new clinical findings.
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    Research cited in this study 8

    1. Fetal Programming of Polycystic Ovary Syndrome by Androgen Excess: Evidence from Experimental, Clinical, and Genetic Association Studies The Journal of Clinical Endocrinology and Metabolism · 2006
    2. Development of Polycystic Ovary Syndrome: Involvement of Genetic and Environmental Factors Andrology · 2005
    3. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS) Human Reproduction · 2003
    4. Adult Polycystic Ovary Syndrome Begins in Childhood Best Practice & Research Clinical Endocrinology & Metabolism · 2002
    5. Polycystic Ovary Syndrome: Clinical and Biochemical Features New England journal of medicine/˜The œNew England journal of medicine · 1995
    6. Acne, Hirsutism, and Alopecia in Adolescent Girls: Clinical Expressions of Androgen Excess Endocrinology and Metabolism Clinics of North America · 1993
    7. Benign Premature Adrenarche: Clinical Features and Serum Steroid Levels Acta Paediatrica · 1983
    8. Serum Androgens in Normal Prepubertal and Pubertal Children and in Children with Precocious Adrenarche The Journal of Clinical Endocrinology & Metabolism · 1976