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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Scientists found new, better-working inhibitors for a hormone-related enzyme.

Researchers developed a new method to find substances in herbs that can block a specific enzyme linked to hair loss.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

A boy with a rare skin condition and kidney disease improved with cyclosporine after steroids failed, suggesting a new treatment approach.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Certain natural compounds can block an enzyme linked to prostate enlargement and hair loss, showing potential for new treatments.

Biodegradable microneedle patches help topical steroids work better for prurigo nodularis.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.

A young woman's rare ovarian tumor was successfully removed, improving her hormonal symptoms.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

Ovarian steroid cell tumors should be considered in adults with hirsutism and high testosterone, with surgery as the main treatment.

The compound was successfully made and shows potential for treating prostate cancer.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

The skin is a complex barrier that protects the body, regulates temperature, and helps with immune responses.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.

Understanding skin structure and development helps diagnose and treat skin disorders.

Accidentally eating a topical steroid may rarely cause acute generalized pustular psoriasis.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Women with female pattern hair loss have higher levels of certain androgens, suggesting increased androgen exposure to hair follicles.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Finasteride doesn't affect erections much, but may decrease libido in men.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Ciclosporin might be a good alternative treatment for certain hearing loss that responds to steroids.