TLDR The compound was successfully made and shows potential for treating prostate cancer.
The document detailed the synthesis of 17α-acetoxy-pregn-4,6-diene-3,20-dione, a compound synthesized with a 70.4% yield from 17α-acetoxyprogesterone and analyzed for its potential as an antiandrogenic prostate cancer treatment. X-ray diffraction showed it has an orthorhombic crystal system and is stabilized by C-H…O interactions and van der Waals forces. The compound's molecular geometry aligns with standard values, with deviations to reduce steric interactions. It demonstrated a high antiandrogenic effect, indicating its promise for prostate cancer therapy. The document also provided synthesis details, crystal structure data, and bond measurements.
15 citations
,
April 2008 in “Steroids” The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
December 1998 in “Acta Crystallographica Section C-crystal Structure Communications” A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.
41 citations
,
March 2007 in “Steroids” New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
3 citations
,
January 2003 in “Synthetic Communications” Scientists made two new chemicals that might help treat diseases caused by male hormones.
51 citations
,
May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” Certain drugs that block specific enzymes can help treat prostate diseases.
18 citations
,
January 2002 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.
