Crystal Structure and Synthesis of 17α-Acetoxy-Pregn-4,6-Diene-3,20-Dione

The document detailed the synthesis of 17α-acetoxy-pregn-4,6-diene-3,20-dione, a compound synthesized with a 70.4% yield from 17α-acetoxyprogesterone and analyzed for its potential as an antiandrogenic prostate cancer treatment. X-ray diffraction showed it has an orthorhombic crystal system and is stabilized by C-H…O interactions and van der Waals forces. The compound's molecular geometry aligns with standard values, with deviations to reduce steric interactions. It demonstrated a high antiandrogenic effect, indicating its promise for prostate cancer therapy. The document also provided synthesis details, crystal structure data, and bond measurements.