TLDR The compound was successfully made and shows potential for treating prostate cancer.
The document detailed the synthesis of 17α-acetoxy-pregn-4,6-diene-3,20-dione, a compound synthesized with a 70.4% yield from 17α-acetoxyprogesterone and analyzed for its potential as an antiandrogenic prostate cancer treatment. X-ray diffraction showed it has an orthorhombic crystal system and is stabilized by C-H…O interactions and van der Waals forces. The compound's molecular geometry aligns with standard values, with deviations to reduce steric interactions. It demonstrated a high antiandrogenic effect, indicating its promise for prostate cancer therapy. The document also provided synthesis details, crystal structure data, and bond measurements.
15 citations,
April 2008 in “Steroids” The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.
December 1998 in “Acta Crystallographica Section C-crystal Structure Communications” A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.
41 citations,
March 2007 in “Steroids” New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
3 citations,
January 2003 in “Synthetic Communications” Scientists made two new chemicals that might help treat diseases caused by male hormones.
51 citations,
May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” Certain drugs that block specific enzymes can help treat prostate diseases.
18 citations,
January 2002 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.
