Crystal Structure and Synthesis of 17α-Acetoxy-Pregn-4,6-Diene-3,20-Dione

June 2010 in “ Journal of Chemical Crystallography ”

Manuel Soriano-García, Armando Zambrano, Marisa Cabeza, Eugene Bratoeff

17α-acetoxy-pregn-4,6-diene-3,20-dione 17α-acetoxyprogesterone antiandrogenic prostate cancer C-H…O interactions van der Waals forces

Studysummary This study determined the crystal structure and conformation of synthesized 17x-Acetoxy-pregn-4,6-diene-3,20-dione, revealing specific molecular interactions and structural details in an orthorhombic crystal system.

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The document detailed the synthesis of 17α-acetoxy-pregn-4,6-diene-3,20-dione, a compound synthesized with a 70.4% yield from 17α-acetoxyprogesterone and analyzed for its potential as an antiandrogenic prostate cancer treatment. X-ray diffraction showed it has an orthorhombic crystal system and is stabilized by C-H…O interactions and van der Waals forces. The compound's molecular geometry aligns with standard values, with deviations to reduce steric interactions. It demonstrated a high antiandrogenic effect, indicating its promise for prostate cancer therapy. The document also provided synthesis details, crystal structure data, and bond measurements.

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