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Finasteride's sexual side effects not caused by androgen deficiency or SRD5A inhibition.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Certain SHBG gene variants, like rs727428, are linked to higher testosterone levels in women with PCOS.

Women with polycystic ovary syndrome have a higher risk of certain fractures.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Women with PCOS have higher androgen levels that decrease with age but are still higher than in women without PCOS.

Certain drugs that block specific enzymes can help treat prostate diseases.

Androgens slow hair growth by altering Wnt signaling in balding cells.

Finasteride and spironolactone both reduce hirsutism, but finasteride lowers androgen levels more.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

Too much androgen can cause hair loss; finasteride may help.

Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

AGA treated with finasteride, minoxidil, and hair transplantation.

Androgens, like DHT, affect hair growth and treatments like finasteride may help.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Dutasteride does not impair mental function in elderly men with enlarged prostate.

Children with classic congenital adrenal hyperplasia have thicker heart fat and are at higher risk for heart problems and early atherosclerosis.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Eating high-glycemic and dairy foods can increase hormones that may cause acne and other health issues.

DHEA stimulates skin oil glands and could help postmenopausal women, with potential for acne and excessive hair growth treatments.

New genes and pathways are important for testosterone production and male sexual development.

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.

New treatments for acne scars are safer and more effective because we understand the causes better.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Long-term finasteride use doesn't change bone density or metabolism.