Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study in mice found that overexpressing Sonic Hedgehog in basal cells caused skin anomalies and a lack of certain hair fibers, underscoring its key role in hair follicle development.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential for disease treatment, but notes challenges in their clinical application.

This study isolated and characterized two distinct types of caspase-like proteases from human epidermis, suggesting their involvement in keratinocyte differentiation and apoptosis processes.

This review examines the potential of biomaterial-based wound dressings in managing diabetic foot ulcers, highlighting their versatility and therapeutic properties for promoting wound healing in individuals with diabetes mellitus.

This review discusses how functionalized hydrogels can modulate the microbiome to aid tissue regeneration and infection control, highlighting their potential to deliver therapeutic agents effectively and support beneficial immune responses.

This study suggests that a chitosan-coated omeprazole-loaded nanoemulgel formulation may effectively treat certain skin infections due to its demonstrated antimicrobial properties and enhanced antibacterial activity.

This review discusses the potential of platelet-rich plasma in regenerative medicine and aging-related diseases but notes that clinical efficacy remains unclear due to varying study results and preparation inconsistencies.

In this study, mice lacking podoplanin in epidermal keratinocytes showed reduced tumor cell invasion and peritumoral lymphangiogenesis, suggesting that keratinocyte-expressed podoplanin contributes to advanced stages of skin tumor progression.

This review highlights the potential of valorizing citrus by-products, particularly hesperidin from orange peels, as sustainable ingredients in skincare for antiaging, pigmentation, wound healing, and UV damage protection, emphasizing hesperidin's role in a circular economy approach.

This review discusses the potential link between gut microbiota alterations and the onset and progression of alopecia areata, identifying it as a possible pathogenetic factor and therapeutic target, but reports no new clinical results.

This review presents evidence supporting the potential of adipose-derived stem cell secretome as a promising cell-free therapy for skin repair, emphasizing its application in wound healing, alopecia, skin rejuvenation, and inflammatory skin diseases.

This review discusses the multifunctional role of PKM2 in promoting cardiac repair and regeneration, highlighting its potential as a therapeutic target in cardiovascular medicine, but reports no new experimental results.

This review discusses the pharmacology and potential therapeutic effects of rare ginsenoside compound K on metabolic disorders but presents no new clinical results, highlighting the need for further studies on its bioavailability and toxicity.

This review synthesizes current knowledge on choriogenesis, the final stage of oogenesis in insects, by exploring the role of follicle cells, regulatory mechanisms of gene expression, and the biochemical makeup of the eggshell, while also highlighting structural diversity and adaptations across insect species.

This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.

In this review, recent advances in long-acting microneedle-based transdermal drug delivery systems are outlined, highlighting biodegradable polymers like PLA, PLGA, and PCL for sustained release and discussing challenges in clinical translation such as consistency in manufacturing and validating long-term efficacy and safety.

This review summarizes advancements in biomedical engineering for hair follicle regeneration, highlighting strategies like cell transplantation and tissue engineering to reconstruct hair follicles, and discusses both their technical limitations and potential future innovations in regenerative medicine.

In this study, researchers observed significant differences in hair follicle microbiome diversity and microbial composition between hair loss and healthy groups, uncovering specific patterns and functional changes associated with female pattern hair loss, which may aid future targeted approaches for androgenetic alopecia.

This study developed and tested Bicalutamide-loaded lipid vesicles in dissolving microarray patches for topical application, finding that they effectively deliver Bicalutamide through murine skin while maintaining a favorable safety profile, suggesting potential to improve treatments for androgenetic alopecia.

This study observed that while low vitamin D levels are associated with increased risk of autoimmune thyroid diseases, evidence from clinical trials on vitamin D supplementation shows inconsistent effects on thyroid function and disease progression, underscoring the need for further research.

This review outlines advances in topical PROTACs for localized protein degradation, focusing on AH-001 and GT20029 for skin conditions, but presents no new clinical trial results.

This review discusses the role of macrophages in chronic wound healing and suggests that understanding their regulation can inform therapeutic approaches, but it reports no new results.

This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.

This study reported five cases of alopecia areata following COVID-19 vaccination, with one patient experiencing worsening symptoms with each vaccine booster.

This review highlights the importance of standardizing pre-analytical procedures for collecting and extracting samples from uncommon biological specimens like breast milk and sweat in clinical metabolomics, to enhance diagnostic and biomarker discovery efforts while minimizing contamination and bias.

This study found that patients with frontal fibrosing alopecia showed significant alterations in protein expression in forehead corneocytes, suggesting the condition may have systemic implications beyond the scalp.

This review explores the potential of cell-mediated drug delivery systems in dermatology, highlighting their ability to target inflamed or diseased skin while discussing applications in diseases like atopic dermatitis and melanoma, along with challenges such as immunogenicity and manufacturing.

This review highlights that a comprehensive approach combining pharmacological, immunomodulatory, and regenerative interventions, including phototherapy enhanced with topical treatments and JAK inhibitors, appears effective and promising in the management of vitiligo by addressing its autoimmune and melanocyte-loss aspects.

This review discusses the role of nanocarrier systems, such as nanoemulsions and liposomes, in delivering antioxidants into the skin to counteract oxidative stress, highlighting recent advancements in topical antioxidant therapy through nanotechnology.

This review discusses using extracellular vesicles as less invasive surrogates for assessing drug-metabolizing enzymes and transporters, suggesting potential advancements in precision therapy, but reports no new clinical results.