This study found that targeting S1PR1 signaling in mouse aortic endothelial cells helps suppress inflammation-related gene expression while revealing diverse and spatially distinct endothelial cell subtypes.
January 2026 in “Journal of Clinical Medicine” This study reviewed literature on the use of robotic systems in plastic and reconstructive surgery, highlighting their application in various procedures despite the predominance of descriptive case reports and a lack of comparative clinical outcomes and long-term data.
December 2025 in “Russian Journal of Skin and Venereal Diseases” This study found that in patients with non-cicatricial alopecia, hair follicles and their sheaths were thinner compared to controls, especially in cases of alopecia areata and telogen effluvium, with notable thinning beginning in the subcutaneous fat tissue.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that hemoglobin α expression in the epidermis is induced by oxidative stress and may function as an antioxidant, contributing to skin barrier function.
March 2023 in “Chemical biology & drug design” This study found that 8% Panax notoginseng saponins may promote hair follicle growth in C57BL/6J mice, potentially through the Wnt/β-catenin signaling pathway.
32 citations
,
May 1999 in “Biochemical and Biophysical Research Communications” This study found that the gene BSSP, a serine protease, is predominantly expressed in sebaceous glands and is overexpressed in nude mouse skin.
1 citations
,
January 2004 in “Linchuang pifuke zazhi” This study found that while SP did not enhance linear hair growth in cultured hair follicles, it prolonged the anagen phase and altered the expression of growth factors and apoptosis-related molecules, suggesting a stimulatory effect on hair growth.
July 2025 in “Journal of Investigative Dermatology” September 2004 in “Experimental Dermatology” This study reports that stress-related neurohormones and factors, such as CRH and SP, can inhibit hair growth and alter immune functions in murine and human hair follicles.
1 citations
,
April 2018 in “Journal of Investigative Dermatology” The Trichodysplasia spinulosa virus protein can cause abnormal hair growth in mice.
27 citations
,
January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified somatostatin as a potential secretory factor contributing to the immune privilege of human hair follicles.
January 2025 in “Pharmaceuticals” This review discusses the role of nanocarrier systems, such as nanoemulsions and liposomes, in delivering antioxidants into the skin to counteract oxidative stress, highlighting recent advancements in topical antioxidant therapy through nanotechnology.
9 citations
,
January 2021 in “Journal of the American Academy of Dermatology”
July 2022 in “Journal of Investigative Dermatology” This study found that Substance P increased mitochondrial activity and biogenesis markers in cultured human scalp hair follicles, suggesting a novel link between stress-related neuropeptide signaling and hair follicle mitochondrial responses.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that TSPyV T antigens can disrupt normal cell differentiation and proliferation in hair follicles and interfollicular epidermis, possibly contributing to trichodysplasia spinulosa pathology.
372 citations
,
December 2004 in “Nature Genetics”
January 2022 in “Elsevier eBooks” This study found that sodium valproate nanospanlastics could be an effective and safer method for treating androgenic alopecia, with results comparable to minoxidil but fewer side effects.
22 citations
,
May 2008 in “Acta veterinaria Scandinavica” This study found that English springer spaniels are predisposed to sebaceous adenitis with more severe clinical signs compared to standard poodles, and many affected dogs are euthanized due to the disease.
26 citations
,
September 2001 in “Journal of Investigative Dermatology” This study found that the serine protease BSSP is strongly expressed in mouse skin during carcinogenesis and is upregulated independently of c-Fos and unaffected by glucocorticoids.
This study found that super-enhancers in squamous cell carcinoma stem cells are distinctly different from those in normal skin stem cells, with ETS2 playing a crucial role in promoting tumor growth.
8 citations
,
September 2003 in “Journal of dermatological science” This study investigated the effects of substance P on human hair growth but found its role in hair follicle physiology remains unclear.
April 2026 in “Reviews in Medical Virology” This review discusses recent updates on trichodysplasia spinulosa, focusing on its seroepidemiology, mechanisms, and treatment options, and reports no new clinical results.
May 2024 in “Reactions weekly” 4 citations
,
September 2015 in “JAAD case reports” This article reviews the characteristics and inheritance patterns of keratosis follicularis spinulosa decalvans, but it does not present new clinical findings, noting the disease's complex and poorly understood pathogenesis.
July 2023 in “Media Dermato Venereologica Indonesiana” This research discusses Stevens-Johnson syndrome and toxic epidermal necrolysis, life-threatening conditions often induced by immune-mediated drug reactions. Optimal management involves early diagnosis, drug withdrawal, and supportive therapy, though evidence for systemic treatments like corticosteroids and cyclosporin remains variable and lacks randomized controlled trial confirmation.
24 citations
,
January 2019 in “Theranostics” This study found that loss of the Pten gene in Lgr5+ hair follicle stem cells promoted squamous cell carcinoma formation through the Akt/β-catenin signaling pathway.
This literature review analyzes existing studies on breast cancer management and underscores the need for improved psychological support throughout diagnosis, treatment, and remission.
51 citations
,
February 2004 in “Journal of Investigative Dermatology” MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.
April 2020 in “Journal of the Endocrine Society” This case report describes a 34-year-old woman with pituitary stalk interruption syndrome, highlighting the need for long-term follow-up due to potential progression from isolated hormonal deficiencies to pan-hypopituitarism.
February 2026 in “Veterinary Sciences” This study found that SPARC-overexpressing adipose-derived mesenchymal stem cells significantly improved various aspects of skin wound healing in dogs, including re-epithelialization, collagen deposition, and angiogenesis, showing promise for enhancing treatment effectiveness under different physiological and pathological conditions.