July 2019 in “Journal of Drug Delivery and Therapeutics” This study developed a validated UV spectrophotometric method that can be used to accurately determine finasteride content in bulk and pharmaceutical formulations.
April 2019 in “The Journal of Urology” This study found that in 45-year-old German men, the use of metformin, insulin, and ACE inhibitors was associated with lower PSA levels, while low dose finasteride resulted in notable PSA decrease.
March 2019 in “European Urology Supplements” This study found that metformin, insulin, and ACE inhibitors were associated with lower PSA levels, but statins did not decrease PSA, whereas low dose finasteride (1 mg) reduced PSA levels similarly to the higher 5 mg dose.
July 2018 in “Journal of Oral and Maxillofacial Surgery” This review chronicles the history and evolution of oral and maxillofacial surgery over the past century, emphasizing advancements in office-based practice and the impact of technological and clinical innovations.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” The authors concluded that Lrig1-positive stem cells are essential for sebaceous gland formation in mice, as their ablation led to temporary sebaceous gland disappearance without affecting hair growth.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that Quantitative Mass Spectrometry Imaging offers precise localization and quantification of active compounds in skin tissues, demonstrating benefits over traditional LC-MS in drug penetration studies.
April 2017 in “Journal of Investigative Dermatology” This study suggests that mutation-targeted siRNA therapy could potentially treat keratitis-ichthyosis-deafness syndrome by selectively reducing harmful GJB2 mutant gene expression in patient-derived keratinocytes.
March 2017 in “International Journal of Women's Dermatology” This special edition focuses on the unique aspects of treating skin conditions in women, including during pregnancy and in diverse populations like women of color and transgender patients.
September 2016 in “Journal of dermatological science” This study identified TSC2 as an important regulator of hair follicle morphogenesis and patterning, with Tsc2cKO mice showing altered hair patterns and frequencies compared to controls.
April 2016 in “Journal of Investigative Dermatology” This study reported that the absence of Lsh in skin led to significant epidermal hyperplasia and altered gene expression, suggesting its crucial role in regulating epidermal proliferation, differentiation, and wound healing.
September 2013 in “Oncology Times” This article discusses the discontinuation of the Bexxar regimen for non-Hodgkin's lymphoma, noting that despite its effectiveness, it was under-prescribed due to marketing and development challenges without reporting new clinical results.
September 2010 in “European Urology Supplements” Opioid use may lower PSA levels, suggesting a possible role in prostate cancer control; PSA testing is useful for detecting prostate cancer; serum triglycerides are not linked to prostate cancer risk; and higher urethral PSA levels may be associated with local hormone activity.
This study developed and validated three analytical techniques for the simultaneous quantification of Finasteride and Tamsulosin Hydrochloride in pharmaceutical dosage forms, with proven accuracy and precision.
February 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Taking 1mg of finasteride daily for hair loss can lower PSA levels by 40-50%, so to keep PSA effective as a cancer screening tool, the PSA value should be doubled during treatment.
This study reported that combining vertical and horizontal sectioning in scalp biopsies allows for a more thorough examination of histological changes in various types of alopecia.
June 2006 in “American Journal of Epidemiology” Long-term diabetes is linked to lower prostate cancer risk.
September 2002 in “Oncology Times” This study presented at the ASCO Annual Meeting reported that the epidermal growth factor receptor antibody ABX-EGF showed preliminary efficacy in renal cell cancer patients, with tolerable side effects, while bortezomib demonstrated clinical benefit in a significant proportion of multiple myeloma patients.
January 1998 in “Hair transplant forum international” This article discusses the contents of the American Journal of Cosmetic Surgery but does not present any new research findings or clinical results.
January 2020 in “Asian Journal of Chemistry” This study demonstrated that FT-Raman spectroscopy is effective for identifying finasteride polymorphs in tablets and detecting the presence of alternative polymorphs down to about 15% concentration.
January 2020 in “Química Nova” This study used Density Functional Theory-based computational methods to analyze finasteride's molecular properties, finding that the GGA/PW91 method closely matches experimental data for vibrational frequencies and geometric parameters.
December 2019 in “International journal of pharmaceutical quality assurance” This study developed and validated a sensitive and accurate UV spectrophotometric method for estimating finasteride concentrations, showing reliable results within a range of 5–25 μg/mL.
September 2019 in “Human Andrology” This study showed that men with androgenetic alopecia had higher serum levels of testosterone and DHT compared to controls, but no difference in PSA levels.
August 2019 in “Journal of The American Academy of Dermatology” No link found between hair loss severity and PSA levels in men.
January 2018 in “프로그램북(구 초록집)” This study found no correlation between serum PSA levels and the severity of androgenetic alopecia at baseline in men.
277 citations
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February 2013 in “Science Signaling” This study found that mitochondrial reactive oxygen species are crucial for normal epidermal differentiation and hair follicle growth, as demonstrated by impaired development in mice lacking these signals due to a keratinocyte-specific TFAM deficiency.
255 citations
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September 2016 in “Frontiers in plant science” This article reviews recent insights into the regulatory role of reactive oxygen species in plant development, highlighting that their mechanisms and signaling pathways remain partially understood.
211 citations
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April 2013 in “Development” In this study, researchers found that the number of dermal papilla cells in hair follicles determines hair size and shape in mice, suggesting potential avenues for addressing hair loss.
188 citations
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May 2009 in “Plant physiology” This study identified 19 specific genes involved in root hair growth and morphogenesis in Arabidopsis, using a combination of computational and experimental methods.
185 citations
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August 2005 in “Autoimmunity Reviews” This review discusses alopecia areata as a model for studying tissue-directed autoimmune diseases and reports no new clinical findings.
174 citations
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November 2016 in “Cell stem cell” This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.